Transcription Factor
| Accessions: | EN1_full (HumanTF 1.0) |
| Names: | EN1, HME1_HUMAN, Homeobox protein en-1, Homeobox protein engrailed-1, Hu-En-1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | Q05925 |
| Notes: | Ensembl ID: ENSG00000163064; Full protein sequence; TF family: homeodomain; Clone source: Megaman |
| Length: | 393 |
| Pfam Domains: | 304-360 Homeobox domain 361-392 Engrailed homeobox C-terminal signature domain |
| Sequence: (in bold interface residues) | 1 MEEQQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGSSGSGSDGDSVPVSPQPAPPSPP 60 61 AAPCLPPLAHHPHLPPHPPPPPPQHLAAPAHQPQPAAQLHRTTNFFIDNILRPDFGCKKE 120 121 QPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPP 180 181 DGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGT 240 241 KYPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNE 300 301 KEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360 361 ATGIKNGLALHLMAQGLYNHSTTTVQDKDESE* |
| Interface Residues: | 291, 304, 305, 306, 307, 345, 346, 348, 349, 352, 353, 356, 357, 360 |
| 3D-footprint Homologues: | 5zfz_A, 1puf_A, 2h1k_B, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1ig7_A, 6fqp_B, 1jgg_B, 2lkx_A, 1nk2_P, 6m3d_C, 1zq3_P, 3lnq_A, 2ld5_A, 7q3o_C, 5zjt_E, 3a01_E, 5hod_A, 3rkq_B, 1puf_B, 1au7_A, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 6es3_K, 1b72_A, 4xrs_G, 2hos_A, 7psx_B, 4j19_B, 2d5v_B, 5flv_I, 1e3o_C, 7xrc_C, 1le8_A, 2xsd_C, 4qtr_D, 1mnm_C, 6fqq_E, 1k61_B, 4xrm_B, 8g87_X, 1o4x_A, 1le8_B, 1du0_A |
| Binding Motifs: | EN1_full_1 syAATTAg EN1_full_2 TaAttrsbyaaTtA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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