Transcription Factor

						

			
Accessions: LHX2_DBD (HumanTF 1.0)

			
Names: Homeobox protein LH-2, LHX2, LHX2_HUMAN, LIM homeobox protein 2, LIM/homeobox protein Lhx2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: P50458
Notes: Ensembl ID: ENSG00000106689; DNA-binding domain sequence; TF family: homeodomain; Clone source: Megaman
Length: 124
Pfam Domains:     32-95 Homeobox KN domain
    43-99 Homeobox domain
Sequence: 
(in bold interface residues)		   1 PRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSY   60
  61 FAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTG  120
 121 TPSG
Interface Residues: 25, 28, 29, 32, 33, 42, 43, 44, 45, 46, 84, 85, 87, 88, 91, 92, 95, 96, 98, 99
3D-footprint Homologues: 5c8e_C, 3d1n_M, 1puf_A, 2h1k_B, 1fjl_B, 5zfz_A, 3cmy_A, 6a8r_A, 3lnq_A, 2lkx_A, 2r5y_A, 1zq3_P, 1nk2_P, 6m3d_C, 1jgg_B, 6es3_K, 7q3o_C, 3l1p_A, 2ld5_A, 7psx_B, 5jlw_D, 4j19_B, 3a01_E, 1puf_B, 2hdd_A, 1b72_A, 5flv_I, 3rkq_B, 1ig7_A, 2hos_A, 5hod_A, 4cyc_A, 2d5v_B, 4xrs_G, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 1le8_B, 6fqq_E, 5zjt_E, 1du0_A, 8g87_X, 4xrm_B
Binding Motifs: LHX2_DBD_1 rCTAATTArc
LHX2_DBD_2 yAATTAmgCTAATTr
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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