Transcription Factor
| Accessions: | T044663_1.02 (CISBP 1.02), Q15916 (JASPAR 2024) |
| Names: | T044663_1.02;, ZBTB6, ZBTB6_HUMAN, Zinc finger and BTB domain-containing protein 6, Zinc finger protein 482, Zinc finger protein with interaction domain |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q15916 |
| Notes: | family:C2H2 ZF |
| Length: | 424 |
| Pfam Domains: | 23-125 BTB/POZ domain 301-323 C2H2-type zinc finger 326-348 C2H2-type zinc finger 328-348 Zinc finger, C2H2 type 340-364 Zinc-finger double domain 354-374 Zinc-finger of C2H2 type 354-376 C2H2-type zinc finger 354-376 Zinc finger, C2H2 type 382-405 C2H2-type zinc finger 382-405 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MAAESDVLHFQFEQQGDVVLQKMNLLRQQNLFCDVSIYINDTEFQGHKVILAACSTFMRD 60 61 QFLLTQSKHVRITILQSAEVGRKLLLSCYTGALEVKRKELLKYLTAASYLQMVHIVEKCT 120 121 EALSKYLEIDLSMKNNNQHTDLCQSSDPDVKNEDENSDKDCEIIEISEDSPVNIDFHVKE 180 181 EESNALQSTVESLTSERKEMKSPELSTVDIGFKDNEICILHVESISTAGVENGQFSQPCT 240 241 SSKASMYFSETQHSLINSTVESRVAEVPGNQDQGLFCENTEGSYGTVSEIQNLEEGYSLR 300 301 HQCPRCPRGFLHVENYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMGIRPFQCTVCL 360 361 KTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSVHGRSSGEKLSRPDLKR 420 421 QSLL |
| Interface Residues: | 311, 312, 313, 314, 315, 317, 318, 319, 321, 322, 326, 336, 337, 338, 339, 340, 341, 342, 343, 344, 364, 365, 366, 367, 368, 369, 370, 371, 372, 375, 392, 393, 394, 395, 396, 398, 399, 403 |
| 3D-footprint Homologues: | 5v3j_F, 6ml4_A, 8ssq_A, 7w1m_H, 2drp_D, 8ssu_A, 5kkq_D, 5ei9_F, 7ysf_A, 6e94_A, 1ubd_C, 5yel_A, 2jpa_A, 2kmk_A, 8cuc_F, 7y3l_A, 1tf3_A, 7n5w_A, 6jnm_A, 1g2f_F, 6blw_A, 6u9q_A, 8gn3_A, 4x9j_A, 2gli_A, 1f2i_J, 5kl3_A, 1tf6_A, 7txc_E, 4m9v_C, 8h9h_G, 2lt7_A, 7y3m_I, 3uk3_C, 5k5i_A, 1llm_D, 5yj3_D, 2wbs_A, 6a57_A |
| Binding Motifs: | M4151_1.02 GrtgATrGAGCCv MA1581.1 dysCTTGAGCCms MA1581.2 sCTTGAGCC |
| Binding Sites: | MA1581.1.1 MA1581.1.10 MA1581.1.11 MA1581.1.12 / MA1581.1.8 MA1581.1.13 / MA1581.1.9 MA1581.1.14 MA1581.1.15 MA1581.1.16 MA1581.1.10 / MA1581.1.17 MA1581.1.11 / MA1581.1.18 MA1581.1.19 MA1581.1.1 / MA1581.1.2 MA1581.1.12 / MA1581.1.20 MA1581.1.2 / MA1581.1.3 MA1581.1.3 / MA1581.1.4 MA1581.1.4 / MA1581.1.5 MA1581.1.6 MA1581.1.5 / MA1581.1.7 MA1581.1.6 / MA1581.1.8 MA1581.1.7 / MA1581.1.9 MA1581.1.13 MA1581.1.14 / MA1581.1.15 MA1581.1.16 MA1581.1.17 MA1581.1.18 MA1581.1.19 MA1581.1.20 MA1581.2.1 / MA1581.2.11 / MA1581.2.13 / MA1581.2.16 / MA1581.2.17 / MA1581.2.5 / MA1581.2.6 MA1581.2.10 MA1581.2.12 / MA1581.2.20 MA1581.2.14 / MA1581.2.15 / MA1581.2.9 MA1581.2.18 MA1581.2.19 MA1581.2.2 MA1581.2.3 MA1581.2.4 MA1581.2.7 / MA1581.2.8 |
| Publications: | Matys V, Kel-Margoulis O.V, Fricke E, Liebich I, Land S, Barre-Dirrie A, Reuter I, Chekmenev D, Krull M, Hornischer K, Voss N, Stegmaier P, Lewicki-Potapov B, Saxel H, Kel A.E, Wingender E. TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes. Nucleic acids research 34:D108-10 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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