Transcription Factor
| Accessions: | T076761_1.02 (CISBP 1.02), E2F3_MOUSE (HOCOMOCO 10), O35261 (JASPAR 2024) |
| Names: | E2f3, T076761_1.02;, E2F-3, E2F3_MOUSE, Transcription factor E2F3 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O35261 |
| Notes: | experiment type:PBM, family:E2F |
| Length: | 457 |
| Pfam Domains: | 170-235 E2F/DP family winged-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAPGTYIQILTTN 60 61 PSTTSCATSLQSGALTAGPLLPSVPGTEPAASSLYTTPQGPSSRVGLLQQPPAPGRGGGG 120 121 GPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYDTSLGLLTK 180 181 KFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSE 240 241 DGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKIS 300 301 GLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHRPMKTNNQDH 360 361 NGNIPKPTSKDLASNNSGHSDCSVSTANLSPLASPANLLQQTEDQIPSNLEGPFVNLLPP 420 421 LLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS |
| Interface Residues: | 148, 150, 170, 206, 207, 208, 209, 211 |
| 3D-footprint Homologues: | 7jn3_E, 1cf7_A, 4yo2_A, 1cf7_B |
| Binding Motifs: | PB0009.1 rhwArGGCGCGCshw PB0113.1 msywyGGCGCCAmrmgs MA0469.1 yTCCCGCccscrsys M0669_1.02 wwwgGCGssy E2F3_MOUSE.H10MO.B|M01055 ssCGCsaMAc |
| Binding Sites: | MA0469.1.1 MA0469.1.10 MA0469.1.11 MA0469.1.12 MA0469.1.13 MA0469.1.14 MA0469.1.15 MA0469.1.16 MA0469.1.17 MA0469.1.18 MA0469.1.19 MA0469.1.2 MA0469.1.20 MA0469.1.3 MA0469.1.4 MA0469.1.5 MA0469.1.6 MA0469.1.7 MA0469.1.8 MA0469.1.9 |
| Publications: | Nevins R. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429 (1992). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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