Transcription Factor

						

			
Accessions: 4y5w_A (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 477
Pfam Domains:    22-115 STAT protein, all-alpha domain
  117-354 STAT protein, DNA binding domain
  365-443 SH2 domain
Sequence: 
(in bold interface residues)		   1 KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAG   60
  61 NGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGETRASLTGRLDEVLRTLVTSCFLVE  120
 121 KQPPQVLKTQTKFQAGVRFLLGLRFLGPAKPPLVRADMVTEKQARETGEIINNTVPLENS  180
 181 IPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGLPIQLQALSLPLVVI  240
 241 VHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEH  300
 301 FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYW  360
 361 SDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFS  420
 421 AKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKMTVE
Interface Residues: 128, 207, 241, 242, 243, 244, 245
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 4y5w_AC CCnnGGAAnnnnnA
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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