Transcription Factor

						

			
Accessions: RARG_DBD (HumanTF 1.0), RARG (HT-SELEX2 May2017)

			
Names: E3VSK7_HUMAN, Fragment, NUP98/RARG fusion protein, RARG, ENSG00000172819
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: E3VSK7
Notes: Ensembl ID: ENSG00000172819; DNA-binding domain sequence; TF family: Nuclear_Receptor; Clone source: Megaman, TF family: Nuclear_receptor experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Nuclear_receptor experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Nuclear_receptor experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: Nuclear_receptor experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 112
Pfam Domains:     20-88 Zinc finger, C4 type (two domains)
Sequence: 
(in bold interface residues)		   1 SEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD   60
  61 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE
Interface Residues: 29, 30, 32, 33, 39, 40, 41, 42, 43, 45, 46, 47, 50, 52, 56, 71, 75, 77, 79, 93, 95, 97, 100
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2a66_A, 8cef_H, 5krb_G, 2nll_B, 1lat_A, 2ff0_A, 1dsz_A, 8hbm_B, 4umm_E, 3cbb_A, 7xv6_B, 4iqr_B, 2han_A, 1hcq_E, 7xvn_C, 2han_B, 1kb2_B, 4yhx_A, 5cbx_B, 4tnt_B, 5cbz_E, 4hn5_B, 5e69_A, 8rm6_A, 3g6t_A, 1r4i_A, 5emc_A, 7prw_B
Binding Motifs: RARG_DBD_1 grGGTCAAAAGGTCAma
RARG_DBD_2 rAGGTCAhcyarAGGTCA
RARG_DBD_3 rRGGTCAmcarAGGTCA
RARG_3 raGGTCAAAAGKTCAm
RARG_4 rAGGTCATGACCTy
RARG_6 rrGGTCAcg
RARG_methyl_1 rrGGTCAaaRGGTCRw
RARG_methyl_2 rAGGTCrYGAMCTy
RARG_methyl_5 raGGTCRcg
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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