Transcription Factor

						

			
Accessions: POU4F2_full (HumanTF 1.0)

			
Names: Brain-3B, Brain-specific homeobox/POU domain protein 3B, Brn-3B, PO4F2_HUMAN, POU domain, class 4, transcription factor 2, POU4F2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q12837
Notes: Ensembl ID: ENSG00000151615; Full protein sequence; TF family: homeodomain+POU; Clone source: ArttuFL1
Length: 410
Pfam Domains:   253-327 Pou domain - N-terminal to homeobox domain
  346-402 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG   60
  61 GGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIV  120
 121 SQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHH  180
 181 HHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAHG  240
 241 LPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTIC  300
 301 RFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSL  360
 361 EAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI*
Interface Residues: 276, 277, 295, 296, 297, 298, 300, 301, 302, 303, 306, 307, 308, 309, 311, 346, 347, 348, 349, 350, 387, 388, 390, 391, 394, 395, 398, 399, 402
3D-footprint Homologues: 3cro_R, 3d1n_M, 7u0g_M, 3l1p_A, 7xrc_C, 1au7_A, 8g87_X, 2xsd_C, 1o4x_A, 1e3o_C, 2d5v_B, 5zfz_A, 1fjl_B, 1ig7_A, 6a8r_A, 1puf_A, 3cmy_A, 2h1k_B, 3lnq_A, 1nk2_P, 1zq3_P, 1jgg_B, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 2r5y_A, 1puf_B, 7psx_B, 5flv_I, 2hdd_A, 1b72_A, 5zjt_E, 3rkq_B, 5hod_A, 3a01_E, 5jlw_D, 1le8_A, 1du0_A, 4qtr_D, 4xrs_G
Binding Motifs: POU4F2_full aTGmATAATTAATkAg
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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