Transcription Factor

						

			
Accessions: UP00629A (UniPROBE 20160601)

			
Names: zinc finger protein 200, ZNF200_REF, ZNFMF
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: zinc finger protein 200: Could have a role in spermatogenesis.
Length: 158
Pfam Domains:     15-37 C2H2-type zinc finger
    15-37 Zinc finger, C2H2 type
    15-37 C2H2-type zinc finger
    15-35 Zinc-finger of C2H2 type
    32-54 Zinc-finger double domain
    43-61 C2H2-type zinc finger
    43-65 Zinc finger, C2H2 type
    43-65 C2H2-type zinc finger
    57-81 Zinc-finger double domain
    71-81 C2H2-type zinc finger
    71-90 Zinc finger, C2H2 type
    71-90 C2H2-type zinc finger
   87-108 Zinc-finger double domain
   98-121 C2H2-type zinc finger
   99-121 Zinc finger, C2H2 type
   99-121 C2H2-type zinc finger
  116-137 Zinc-finger double domain
  127-141 C2H2-type zinc finger
  127-149 Zinc finger, C2H2 type
  129-149 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 SIIALTRNRRTRRWYTCPLCGKQFNESSYLISHQRTHTGEKPYDCNHCGKSFNHKTNLNK   60
  61 HERIHTGEKPYSCSQCGKNFRQNSHRSRHEGIHIREKIFKCPECGKTFPKNEEFVLHLQS  120
 121 HEAERPYGCKKCGRRFGRLSNCTRHEKTHSACKTRKQK
Interface Residues: 1, 2, 5, 7, 11, 15, 25, 26, 27, 28, 29, 31, 32, 34, 35, 38, 53, 54, 55, 56, 57, 59, 60, 61, 81, 82, 83, 84, 85, 86, 87, 88, 89, 92, 109, 110, 111, 112, 113, 115, 116, 138, 139, 140, 141, 144
3D-footprint Homologues: 5v3j_F, 8ssu_A, 2kmk_A, 7n5w_A, 3uk3_C, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 1mey_C, 5kl3_A, 2drp_D, 1f2i_J, 6u9q_A, 5und_A, 2gli_A, 1g2f_F, 1tf6_A, 7w1m_H, 4x9j_A, 6blw_A, 5kkq_D, 1ubd_C, 8h9h_G, 7eyi_G, 7y3m_I, 6e94_A, 6wmi_A, 2i13_A, 6a57_A, 2jpa_A, 5k5i_A, 7txc_E, 8ssq_A, 1llm_D, 2wbs_A, 6ml4_A, 5yel_A, 5ei9_F, 8gn3_A, 4m9v_C, 7ysf_A, 2lt7_A, 5yj3_D, 6dta_B, 5k5l_F
Binding Motifs: UP00629A_1 sswkkwaadGGAKACmmwswsrw
Binding Sites: GATATCCC
GGATATCA
AAGGAGAC
AGGAGACC
AGGATACC
AGGGAGAC
AGGGATAT
GGAGACAA
GGAGACCA
GGAGACCC
GGATACCA
GGATACCC
GGATACTA
GGATATCC
GGGAGACA
GGGAGACC
GGGATACC
GGGGAGAC
GGGGATAC
GGTCTCCA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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