Transcription Factor
| Accessions: | Q86XU0 (JASPAR 2024) |
| Names: | ZN677_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q86XU0 |
| Length: | 584 |
| Pfam Domains: | 9-48 KRAB box 255-273 Zinc-finger double domain 263-283 C2H2-type zinc finger 263-285 Zinc finger, C2H2 type 263-285 C2H2-type zinc finger 277-301 Zinc-finger double domain 290-313 C2H2-type zinc finger 291-313 C2H2-type zinc finger 291-313 Zinc finger, C2H2 type 305-329 Zinc-finger double domain 319-341 C2H2-type zinc finger 319-341 Zinc finger, C2H2 type 333-356 Zinc-finger double domain 346-356 C2H2-type zinc finger 347-369 C2H2-type zinc finger 347-369 Zinc finger, C2H2 type 362-385 Zinc-finger double domain 374-395 C2H2-type zinc finger 375-397 C2H2-type zinc finger 375-397 Zinc finger, C2H2 type 389-414 Zinc-finger double domain 403-425 C2H2-type zinc finger 403-425 Zinc finger, C2H2 type 417-440 Zinc-finger double domain 430-449 C2H2-type zinc finger 431-453 Zinc finger, C2H2 type 431-453 C2H2-type zinc finger 445-468 Zinc-finger double domain 459-481 Zinc finger, C2H2 type 459-481 C2H2-type zinc finger 474-497 Zinc-finger double domain 486-507 C2H2-type zinc finger 487-509 Zinc finger, C2H2 type 487-509 C2H2-type zinc finger 501-526 Zinc-finger double domain 514-535 C2H2-type zinc finger 515-537 C2H2-type zinc finger 515-537 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MALSQGLFTFKDVAIEFSQEEWECLDPAQRALYRDVMLENYRNLLSLDEDNIPPEDDISV 60 61 GFTSKGLSPKENNKEELYHLVILERKESHGINNFDLKEVWENMPKFDSLWDYDVKNYKGM 120 121 PLTCNKNLTHRKDQQHNKSSIHFSLKQSVSIRDSAHQYFIHDKPFIRNLLKLKNNIRYAG 180 181 NKYVKCFENKIGLSLQAQLAELQRFQTGEKMYECNPVEKSINSSSVSPLPPCVKNICNKY 240 241 RKILKYPLLHTQYGRTHIREKSYKCNDCGKAFSKSSNLTNHQRIHSGQRPYKCNECGKAF 300 301 NQCSNLTRHQRVHTGEKPYQCNICGKVCSQNSNLASHQRMHTGEKPYKCNECGKAFIQRS 360 361 HLWGHERIHTGEKPYKCNECDKAFAERSSLTQHKRIHTGEKPYICNECGKAFKQCSHLTR 420 421 HQNIHPGEKPHKCNVCGRAFIQSSSLVEHQRIHTGEKPYKCNKCDKAFIKRSHLWGHQRT 480 481 HTGEKPYKCTECGKAFTERSNLTQHKKIHTGEKPYKCTECGKAFTQFANLTRHQKIHIEK 540 541 KHCKHNIHGNALFQSSNLGDHQKSYNREKHIKYNETKIKYSSCT |
| Interface Residues: | 263, 274, 275, 276, 277, 280, 284, 301, 302, 303, 304, 305, 307, 308, 310, 311, 314, 329, 330, 331, 332, 333, 336, 339, 340, 357, 358, 359, 360, 361, 363, 364, 365, 385, 386, 387, 388, 389, 391, 392, 413, 414, 415, 416, 417, 419, 420, 424, 441, 442, 443, 444, 445, 447, 448, 452, 454, 468, 469, 470, 471, 472, 473, 476, 480, 497, 498, 499, 500, 501, 502, 503, 504, 505, 525, 526, 527, 528, 529, 530, 532, 533, 554, 556, 557, 560 |
| 3D-footprint Homologues: | 2kmk_A, 8ssq_A, 7w1m_H, 8ssu_A, 1tf6_A, 2i13_A, 1ubd_C, 7n5w_A, 2wbs_A, 6u9q_A, 1mey_C, 1f2i_J, 5k5i_A, 6ml4_A, 4x9j_A, 6blw_A, 8h9h_G, 6e94_A, 2jpa_A, 1tf3_A, 7txc_E, 5kl3_A, 6wmi_A, 5v3j_F, 3uk3_C, 6jnm_A, 6a57_A, 5yel_A, 5ei9_F, 5und_A, 8gn3_A, 1llm_D, 7y3m_I, 2gli_A, 7ysf_A, 5kkq_D, 7eyi_G, 2lt7_A, 8cuc_F, 1g2f_F, 5k5l_F, 7y3l_A, 2drp_D, 4m9v_C, 5yj3_D |
| Binding Motifs: | UN0337.1 yhratAAGAACAGchw MA2101.1 ratAAGAACAGc |
| Binding Sites: | UN0337.1.1 UN0337.1.10 / UN0337.1.7 UN0337.1.11 UN0337.1.12 / UN0337.1.8 UN0337.1.13 UN0337.1.11 / UN0337.1.14 UN0337.1.12 / UN0337.1.15 UN0337.1.13 / UN0337.1.16 UN0337.1.14 / UN0337.1.17 UN0337.1.15 / UN0337.1.18 UN0337.1.16 / UN0337.1.19 UN0337.1.2 UN0337.1.17 / UN0337.1.20 UN0337.1.3 UN0337.1.2 / UN0337.1.4 UN0337.1.5 UN0337.1.3 / UN0337.1.6 UN0337.1.7 UN0337.1.4 / UN0337.1.8 UN0337.1.5 / UN0337.1.9 UN0337.1.10 UN0337.1.18 UN0337.1.19 UN0337.1.20 UN0337.1.6 UN0337.1.9 MA2101.1.1 MA2101.1.10 MA2101.1.11 MA2101.1.12 MA2101.1.13 MA2101.1.14 MA2101.1.15 MA2101.1.16 MA2101.1.17 MA2101.1.18 MA2101.1.19 MA2101.1.2 MA2101.1.20 MA2101.1.3 MA2101.1.4 MA2101.1.5 MA2101.1.6 MA2101.1.7 MA2101.1.8 MA2101.1.9 |
| Publications: | Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.