Transcription Factor
| Accessions: | TBX1_DBD (HumanTF 1.0), TBX1 (HT-SELEX2 May2017) |
| Names: | T-box protein 1, T-box transcription factor TBX1, TBX1, TBX1_HUMAN, Testis-specific T-box protein, ENSG00000184058 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | O43435 |
| Notes: | Ensembl ID: ENSG00000184058; DNA-binding domain sequence; TF family: T-box; Clone source: Gene synthesis, TF family: T_box experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: T_box experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 230 |
| Pfam Domains: | 26-211 T-box |
| Sequence: (in bold interface residues) | 1 EGPGASCAAAAKAPVKKNAKVAGVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVK 60 61 LFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQW 120 121 MKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFE 180 181 ETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLMS |
| Interface Residues: | 51, 188, 189, 205, 208, 209 |
| 3D-footprint Homologues: | 1xbr_B, 6f59_B, 2x6v_A, 4a04_B, 1h6f_B, 5flv_I |
| Binding Motifs: | TBX1_DBD_1 AgGTGTGAAAaaAgGTGTGA TBX1_DBD_2 AGGTGTGAAwWTCACACCT TBX1_DBD_3 AGGTGTGA TBX1_DBD_4 TTTCACACCTywrAkGTGTGArR TBX1_DBD_5 TTCACACCTmwAGGTGTGAr TBX1_2 krrGGTGTGAar TBX1_methyl_1 kkaGGTGTGaat |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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