Transcription Factor
| Accessions: | 3rkq_B (3D-footprint 20231221) |
| Names: | Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P52952 |
| Length: | 57 |
| Pfam Domains: | 3-56 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKS |
| Interface Residues: | 2, 3, 4, 5, 6, 44, 45, 47, 48, 51, 52, 55, 56 |
| 3D-footprint Homologues: | 5zfz_A, 4j19_B, 3a01_E, 5zjt_E, 3cmy_A, 6a8r_A, 3d1n_M, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 1jgg_B, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1au7_A, 2hos_A, 5jlw_D, 4cyc_A, 1b72_A, 4xrs_G, 5flv_I, 3lnq_A, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 2h8r_B, 1puf_B, 8g87_X, 4qtr_D, 1k61_B, 4xrm_B, 1o4x_A, 3l1p_A, 1mnm_C, 1du0_A |
| Binding Motifs: | 3rkq_AB TCAAGAGnnnnnCACTTCA 3rkq_B CTCTtGA |
| Binding Sites: | 3rkq_C 3rkq_D |
| Publications: | Pradhan L, Genis C, Scone P, Weinberg E.O, Kasahara H, Nam H.J. Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry 51:6312-9 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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