Transcription Factor
| Accessions: | 3rkq_B (3D-footprint 20231221) |
| Names: | Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P52952 |
| Length: | 57 |
| Pfam Domains: | 3-56 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKS |
| Interface Residues: | 2, 3, 4, 5, 6, 44, 45, 47, 48, 51, 52, 55, 56 |
| 3D-footprint Homologues: | 5zfz_A, 4j19_B, 3a01_E, 6a8r_A, 3d1n_M, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 5zjt_E, 3cmy_A, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1au7_A, 2hos_A, 5jlw_D, 4cyc_A, 1b72_A, 4xrs_G, 5flv_I, 3lnq_A, 1jgg_B, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 2h8r_B, 1k61_B, 4xrm_B, 1o4x_A, 3l1p_A, 1mnm_C, 1du0_A, 1puf_B, 8g87_X, 4qtr_D |
| Binding Motifs: | 3rkq_AB TCAAGAGnnnnnCACTTCA 3rkq_B CTCTtGA |
| Binding Sites: | 3rkq_C 3rkq_D |
| Publications: | Pradhan L, Genis C, Scone P, Weinberg E.O, Kasahara H, Nam H.J. Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry 51:6312-9 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.