Transcription Factor
| Accessions: | BHE40_HUMAN (HOCOMOCO 10), O14503 (JASPAR 2024) |
| Names: | BHE40_HUMAN, bHLHb2, bHLHe40, Class B basic helix-loop-helix protein 2, Class E basic helix-loop-helix protein 40, DEC1, Differentially expressed in chondrocytes protein 1, Enhancer-of-split and hairy-related protein 2, SHARP-2, Stimulated by retinoic acid gene 13 protein |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 412 |
| Pfam Domains: | 57-107 Helix-loop-helix DNA-binding domain 140-181 Hairy Orange |
| Sequence: (in bold interface residues) | 1 MERIPSAQPPPACLPKAPGLEHGDLPGMYPAHMYQVYKSRRGIKRSEDSKETYKLPHRLI 60 61 EKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIA 120 121 LQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVS 180 181 ELLQGGTSRKPSDPAPKVMDFKEKPSSPAKGSEGPGKNCVPVIQRTFAHSSGEQSGSDTD 240 241 TDSGYGGESEKGDLRSEQPCFKSDHGRRFTMGERIGAIKQESEEPPTKKNRMQLSDDEGH 300 301 FTSSDLISSPFLGPHPHQPPFCLPFYLIPPSATAYLPMLEKCWYPTSVPVLYPGLNASAA 360 361 ALSSFMNPDKISAPLLMPQRLPSPLPAHPSVDSSVLLQALKPIPPLNLETKD |
| Interface Residues: | 56, 57, 58, 60, 61, 64, 65, 91 |
| 3D-footprint Homologues: | 1an4_A, 7ssa_L, 5eyo_A, 7d8t_A, 4h10_A, 7xi3_A, 5nj8_D, 7f2f_B, 5v0l_A, 1am9_A, 7rcu_E, 4zpk_A, 6g1l_A, 8osl_P, 4h10_B, 8osl_O |
| Binding Motifs: | MA0464.2 vkCACGTGmc BHE40_HUMAN.H10MO.A|M01038 kCACGTGAs MA0464.3 kCACGTGm |
| Publications: | Jones S. An overview of the basic helix-loop-helix proteins. Genome Biol : (2004;5(6):226.). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.