Transcription Factor

Accessions: 1ttu_A (3D-footprint 20231221)
Names: lin-12 And Glp-1 transcriptional regulator, Q8MXE7_CAEEL
Organisms: Caenorhabditis elegans
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q8MXE7
Length: 435
Pfam Domains: 23-155 LAG1, DNA binding
159-311 Beta-trefoil DNA-binding domain
352-433 IPT/TIG domain
Sequence:
(in bold interface residues)
1 VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQGWKLKKD 60
61 RVAQLYKTEQQATELVAYIGIGSDTSERQQLDFPNIYDYCAAKTLYISDSDKRKYFDLNA 120
121 QFFYGCGMEIGGFVSQRIKVISKPSKKKQSMKNTDCKYLCIASGTKVALFNRLRSQTVST 180
181 RYLHVEGNAFHASSTKWGAFTIHLFDDERGLQETDNFAVRDGFVYYGSVVKLVDSVTGIA 240
241 LPRLRIRKVDKQQVILDASCSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINE 300
301 HRHQINDGAAWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGEASRVELHGRD 360
361 FKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRTTGDVEVPISLVRD 420
421 DGVVYSSGLTFSYKS
Interface Residues: 35, 38, 40, 142, 143, 146, 174, 175, 176
3D-footprint Homologues: 3iag_C, 5e24_E, 3brd_A
Binding Motifs: 1ttu_A tGngA
Binding Sites: 1ttu_B
1ttu_C
Publications: Kovall R.A, Hendrickson W.A. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. The EMBO journal 23:3441-51 (2004). [Pubmed]
Related annotations: PaperBLAST

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