Transcription Factor

						

			
Accessions: 5z6z_A (3D-footprint 20231221), 5zfw_A (3D-footprint 20231221), 5zfz_A (3D-footprint 20231221)

			
Names: Double homeobox protein 10, Double homeobox protein 4, DUX4_HUMAN, Double homeobox protein 4-like protein 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q9UBX2
Length: 122
Pfam Domains:      2-56 Homeobox domain
    23-55 Homeobox KN domain
   68-122 Homeobox domain
   91-121 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 GRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLRQH   60
  61 RRESPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRA  120
 121 RH
Interface Residues: 2, 3, 5, 46, 47, 50, 51, 54, 55, 58, 68, 69, 70, 71, 109, 110, 112, 113, 116, 117, 120, 121
3D-footprint Homologues: 3d1n_M, 5zfz_A, 1nk2_P, 4j19_B, 2h8r_B, 1au7_A, 1ic8_B, 2xsd_C, 7xrc_C, 3l1p_A, 8g87_X, 4xrm_B, 6m3d_C, 2h1k_B, 1ig7_A, 1puf_A, 1fjl_B, 3cmy_A, 6a8r_A, 1jgg_B, 3lnq_A, 2lkx_A, 1zq3_P, 2ld5_A, 2hos_A, 7q3o_C, 5jlw_D, 4cyc_A, 6es3_K, 4xrs_G, 3a01_E, 5flv_I, 1puf_B, 5zjt_E, 2hdd_A, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 2r5y_A, 1e3o_C, 1le8_A, 1du0_A, 4qtr_D
Binding Motifs: 5z6z_A TGATtAgATTAG
5zfw_A CTAATCTnaTCA
5zfz_A TGAAnaGATTAG
Binding Sites: 5z6z_D
5z6z_E
5zfw_D
5zfw_E
5zfz_D
5zfz_E
			
Publications: Li Y, Wu B, Liu H, Gao Y, Yang C, Chen X, Zhang J, Chen Y, Gu Y, Li J, Ma J, Gan J. Structural basis for multiple gene regulation by human DUX4. Biochem Biophys Res Commun 505:1161-1167 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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