Transcription Factor
| Accessions: | T015231_1.02 (CISBP 1.02), ITF2_MOUSE (HOCOMOCO 10) |
| Names: | T015231_1.02;, Tcf4, Class A helix-loop-helix transcription factor ME2, Immunoglobulin transcription factor 2, ITF-2, ITF2_MOUSE, MITF-2, SEF-2, SL3-3 enhancer factor 2, TCF-4, Transcription factor 4 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 670 |
| Pfam Domains: | 568-621 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWG 60 61 TGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRENVQGC 120 121 HQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNARRRPLHSSAMEVQTKKVRKVPPGLP 180 181 SSVYAPSASTADYNRDSPGYPSSKPAASTFPSSFFMQDGHHSSDPWSSSSGMNQPGYGGM 240 241 LGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPAN 300 301 GTDSIMANRGTGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAV 360 361 WSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAVPGGHGDMHGI 420 421 MGPSHNGAMGSLGSGYGTSLLSANRHSLMVGAHREDGVALRGSHSLLPNQVPVPQLPVQS 480 481 ATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDI 540 541 KSITRSRSSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKS 600 601 DKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGM 660 661 GDAANHMGQM |
| Interface Residues: | 569, 572, 573, 575, 576, 577, 579, 580 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 6od3_F, 7d8t_A, 6g1l_A, 2ql2_D, 2ypa_B, 2ql2_A |
| Binding Motifs: | M0219_1.02 sCAGrTGyk ITF2_MOUSE.H10MO.B|M01180 vCAGGTGyr |
| Related annotations: | PaperBLAST |
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