Transcription Factor
| Accessions: | HOXA13_full (HumanTF 1.0), HOXA13_Full (HumanTF2 1.0) |
| Names: | Homeobox protein Hox-1J, Homeobox protein Hox-A13, HOXA13, HXA13_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P31271 |
| Notes: | Ensembl ID: ENSG00000106031; Full protein sequence; TF family: homeodomain; Clone source: hORFeome, Ensembl ID: ENSG00000106031; Construct type: Full length protein used in HT-SELEX with mixed proteins; TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013 |
| Length: | 389 |
| Pfam Domains: | 79-133 Hox protein A13 N terminal 124-224 Hox protein A13 N terminal 323-379 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPH 60 61 PAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAASAYSSAPGEAPPSAAAAA 120 121 AAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYP 180 181 CARMGPHPNAIKSCAQPASAAAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPY 240 241 HHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQAQPPH 300 301 LWKSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTN 360 361 LSERQVTIWFQNRRVKEKKVINKLKTTS* |
| Interface Residues: | 323, 324, 325, 326, 364, 365, 367, 368, 371, 372, 375, 376, 379 |
| 3D-footprint Homologues: | 1fjl_B, 2h1k_B, 5zfz_A, 1puf_A, 1ig7_A, 3cmy_A, 6a8r_A, 2lkx_A, 6m3d_C, 2p0j_A, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 6es3_K, 7q3o_C, 2ld5_A, 4xrs_G, 1b72_A, 3rkq_B, 5flv_I, 3a01_E, 2hdd_A, 5zjt_E, 4cyc_A, 1puf_B, 5hod_A, 2hos_A, 2r5y_A, 7psx_B, 5jlw_D, 2xsd_C, 1le8_A, 7xrc_C, 6ryd_F, 1e3o_C, 1au7_A, 1o4x_A, 1mnm_C, 1du0_A, 4qtr_D, 1k61_B |
| Binding Motifs: | HOXA13_full_1 cyaATAAAam HOXA13_full_2 wCTCGTAAAAm CUX1_HOXA13_1 ATCGATyAysycrTmAA CUX1_HOXA13_2 cyCrTAAAwATyGATc ETV5_HOXA13 rmcGGAwGYcgTaaa GCM1_HOXA13 rTGcGGGTmaTaAa GCM2_HOXA13 ATRCGGGTaATAAAa HOXA13_MEIS1 dmyrTAAAaCTGTC MEIS1_HOXA13 symrTaAaacTGTCA MEIS2_HOXA13 CTCGTAAAmCTGTCA MYBL1_HOXA13 CTCRTAAAwwakkrmCGTTr TEAD4_HOXA13_1 CTcGTAAATwCcr TEAD4_HOXA13_2 GGwATGCycrTWAA TEAD4_HOXA13_2_3 rCATwCCrcrmmmscymrTAAA TEAD4_HOXA13_2_3_4 rCATwCcdmrswaTTTAyrag |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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