Transcription Factor
| Accessions: | PROX1_DBD (HumanTF 1.0), PROX1 (HT-SELEX2 May2017) |
| Names: | Homeobox prospero-like protein PROX1, Prospero homeobox protein 1, PROX-1, PROX1, PROX1_HUMAN, ENSG00000117707 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q92786 |
| Notes: | Ensembl ID: ENSG00000117707; DNA-binding domain sequence; TF family: Homeodomain+Prospero; Clone source: Megaman, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 176 |
| Pfam Domains: | 13-173 Homeobox prospero-like protein (PROX1) |
| Sequence: (in bold interface residues) | 1 LQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLI 60 61 KWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERF 120 121 LEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE |
| Interface Residues: | 61, 64, 65, 68, 69, 113, 115 |
| 3D-footprint Homologues: | 1xpx_A, 1zq3_P, 2i0q_A |
| Binding Motifs: | PROX1_DBD yAAGACGyCTTa PROX1_2 kAaGRCGTCtTs PROX1_methyl_1 yAAGryGTCTTr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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