Transcription Factor
| Accessions: | UP00620B (UniPROBE 20160601) |
| Names: | homeobox protein SIX6, Homeodomain protein OPTX2, MCOPCT2, Optic homeobox 2, Sine oculis homeobox homolog 6, SIX6_H141N, Six9 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein SIX6: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008] |
| Length: | 81 |
| Pfam Domains: | 15-66 Homeobox domain 30-64 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 FPLPRTIWDGEQKTHCFKERTRNLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKN 60 61 RRQRDRAAAAKNRLQQQVLSQ |
| Interface Residues: | 5, 13, 14, 15, 16, 52, 53, 55, 56, 59, 60, 63, 64, 66, 67 |
| 3D-footprint Homologues: | 4xrs_G, 2r5y_A, 2lkx_A, 3l1p_A, 1le8_B, 1k61_B, 1mnm_C, 5jlw_D, 2ld5_A, 2h8r_B, 1ic8_B, 7xrc_C, 1le8_A, 1ig7_A, 2xsd_C, 1e3o_C, 1au7_A, 4j19_B, 7q3o_C, 1b72_A, 4qtr_D, 3cmy_A, 1nk2_P, 6fqq_E, 5hod_A, 3rkq_B, 1zq3_P, 6a8r_A, 1du0_A, 4xrm_B, 3d1n_M, 2hdd_A, 1o4x_A, 4cyc_A, 2d5v_B, 8g87_X, 6es3_K, 1puf_A, 7psx_B, 1jgg_B, 5zfz_A, 3a01_E, 2h1k_B, 6fqp_B, 1fjl_B, 5flv_I, 3lnq_A, 1puf_B, 5zjt_E, 6m3d_C |
| Binding Motifs: | UP00620B_1 wtawhakrgrTATCAwwTAmym UP00620B_2 rwrrwdrrgRTATCAhtyrtkm |
| Binding Sites: | AATGATAC AGATATCA AGGTATCA AGTATCAT AGTGATAC ATGATACC ATGATACG ATGATATC ATGATATG ATTGATAC CGGTATCA GATACCCC GATATCAA GATATCAC GATGATAC GGATATCA GGGTATCA GGTATCAA GGTATCAC GTATCATA TGATATCA ACATATCA GAGTATCA GGTGATAC GTGTATCA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.