Transcription Factor
| Accessions: | Q9Z0Y9 (JASPAR 2024) |
| Names: | Liver X receptor alpha, NR1H3_MOUSE, Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR-alpha |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9Z0Y9 |
| Length: | 445 |
| Pfam Domains: | 95-162 Zinc finger, C4 type (two domains) 241-424 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAE 60 61 PTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF 120 121 RRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ 180 181 EEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAP 240 241 DPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLET 300 301 SRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAI 360 361 SIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHS 420 421 EQVFALRLQDKKLPPLLSEIWDVHE |
| Interface Residues: | 105, 107, 114, 117, 118, 121, 122, 146, 176, 193, 195 |
| 3D-footprint Homologues: | 6l6q_B, 7wnh_D, 3g9m_B, 7xv6_B, 2han_A, 7xvn_C, 2han_B, 8cef_H, 2a66_A, 2nll_B, 8hbm_B, 2ff0_A, 3g6t_A, 8rm6_A, 7prw_B, 5cbx_B, 5cbz_E |
| Binding Motifs: | MA0494.1 TGaCCtvrrGTrACCyykg MA0494.2 TGaCCtvrrGTrACCy MA2337.1 AGGkCA |
| Binding Sites: | MA2337.1.1 / MA2337.1.10 / MA2337.1.11 / MA2337.1.13 / MA2337.1.14 / MA2337.1.15 / MA2337.1.17 / MA2337.1.19 / MA2337.1.2 / MA2337.1.20 / MA2337.1.3 / MA2337.1.4 / MA2337.1.5 / MA2337.1.8 / MA2337.1.9 MA0494.1.1 MA0494.1.10 MA0494.1.11 MA0494.1.12 MA0494.1.13 MA0494.1.14 MA0494.1.15 MA0494.1.16 MA0494.1.17 MA0494.1.18 MA0494.1.19 MA0494.1.2 MA0494.1.20 MA0494.1.3 MA0494.1.4 MA0494.1.5 MA0494.1.6 MA0494.1.7 MA0494.1.8 MA0494.1.9 MA0494.2.1 MA0494.2.10 MA0494.2.11 MA0494.2.12 MA0494.2.13 MA0494.2.14 MA0494.2.15 MA0494.2.16 MA0494.2.17 MA0494.2.18 MA0494.2.19 MA0494.2.2 MA0494.2.20 MA0494.2.3 MA0494.2.4 MA0494.2.5 MA0494.2.6 MA0494.2.7 MA0494.2.8 MA0494.2.9 MA2337.1.12 / MA2337.1.16 / MA2337.1.18 / MA2337.1.6 / MA2337.1.7 |
| Publications: | Shen Q, Bai Y, Chang K.C, Wang Y, Burris T.P, Freedman L.P, Thompson C.C, Nagpal S. Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes. The Journal of biological chemistry 286:14554-63 (2011). [Pubmed] Penvose A, Keenan JL, Bray D, Ramlall V, Siggers T. Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity. Nat Commun 10:2514 (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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