Transcription Factor
| Accessions: | UP00365A (UniPROBE 20160601) |
| Names: | HLH-30 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P91527 |
| Description: | Helix Loop Helix Protein 30: W02C12.3 is orthologous to the human gene TRANSCRIPTION FACTOR BINDING TO IGHM ENHANCER 3 (TFE3; OMIM:314310), which when mutated leads to disease. |
| Length: | 497 |
| Pfam Domains: | 238-290 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 ADDDDRVDISNETLASLVGRPMSSSGNRIRATPSRRRLVSAPTNPRWSPSADDRRLFSYV 60 61 SSMRSDSNSSSKSPSPPSAKMSKRPNGPYSVRKYQPRGSPPSDGSDKIHRFGESPTPGGV 120 121 GGVFGTELDDLIIDELMGMEDDQRMRPGATRPMTIGGEKTMSMARPIPGASSRAGSGHSG 180 181 SPITIPNAMSNNFRQVVSSSAPTSSIDIEKMIGAVSNGGGNSGGDNDPEDYYRDRRKKDI 240 241 HNMIERRRRYNINDRIKELGQMLPKNTSEDMKLNKGTILKASCDYIRVLQKDREQAMKTQ 300 301 QQQKSLESTAHKYADRVKELEEMLARQGVQVPPSHLPPIPKVIERPIKQEIDESPPNHTP 360 361 TGSFVSSSGFLSEVTNNTAAMQITSPNDSRPNNFMNNSAPSDSFFSVGSASPPDYRTSSG 420 421 TASWKLPGSNAFSDLMMDDLNPMMNGDPLISSAGAHPSPHFHSSQMSPDIHWDASGFSPD 480 481 PINTQQSNSGHYHMDFS |
| Interface Residues: | 238, 240, 241, 242, 244, 245, 246, 248, 249, 273, 275, 277, 280, 281, 282, 285, 329 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 6g1l_A, 4zpk_A, 1am9_A, 7ssa_L, 5nj8_D, 3mva_O, 6od3_F, 5eyo_A, 4h10_A, 7d8t_A, 5gnj_I, 7xi3_A, 5v0l_A, 4h10_B, 7f2f_B, 5i50_B, 8osl_P, 2ypa_A, 2ypa_B, 8osl_O, 7xhv_B, 7xi3_B, 5t2n_A |
| Binding Motifs: | UP00365A_1 wswaTCACGTGAywawy |
| Binding Sites: | AAATAATA AACACGTG ACACGTGA ACCACGTG AGCACGTG ATATAATA ATCACATG ATCACGTG ATTATTTA CACGTGAC CACGTGCA CATGTGAC CCACGTGA CTCGTGAC GCACGTGA GCACGTGC TATATATA TCACATGA TCACGTGA TCATATGA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.