Transcription Factor

						

			
Accessions: 5yi2_B (3D-footprint 20231221), 5yi2_F (3D-footprint 20231221), 5yi2_I (3D-footprint 20231221), 5yi2_J (3D-footprint 20231221)

			
Names: Q9CDU5_LACLA, Zinc transport transcriptional regulator
Organisms: Lactococcus lactis, Lactococcus lactis subsp. lactis (strain IL1403)
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 145
Pfam Domains:     35-92 MarR family
    35-90 MarR family
    36-81 Winged helix-turn-helix DNA-binding
    36-99 Winged helix DNA-binding domain
    41-84 Transcriptional regulator
    41-82 Bacterial regulatory protein, arsR family
    42-81 Iron dependent repressor, N-terminal DNA binding domain
   42-114 TFIIE alpha subunit
Sequence: 
(in bold interface residues)		   1 MSLANQIDQFLGTIMQFAENKHEILLGKCESDVKLTSTQEHILMLLAEQISTNAKIAEKL   60
  61 KISPAAVTKALKKLQEQELIKSSRATNDERVVLWSLTEKAVPVAKEHATHHEKTLSTYQE  120
 121 LGNKFTDEEQEVISKFLSALTEEFQ
Interface Residues: 36, 38, 53, 63, 64, 65, 66, 68, 69, 70, 73, 90
3D-footprint Homologues: 4kdp_B, 7el3_B, 6jbx_A, 3q5f_A, 5yi2_J, 6c2s_C, 1z9c_A, 5hlg_E, 3zpl_B, 8c7s_A, 4aik_A
Binding Motifs: 5yi2_AB TTaAAnAGTTAAA
5yi2_EF TtaACnAGTTAA
5yi2_IJ TwAACyrGTTAA
5yi2_J rGTtAA
Binding Sites: 5yi2_C / 5yi2_D / 5yi2_G / 5yi2_H / 5yi2_K / 5yi2_L
			
Publications: Zhu R, Song Y, Liu H, Yang Y, Wang S, Yi C, Chen PR. Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation. Proc Natl Acad Sci U S A 114:13661-13666 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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