Transcription Factor
| Accessions: | Hoxa11_DBD (HumanTF 1.0), UP00246A (UniPROBE 20160601) |
| Names: | Homeobox protein Hox-1.9, Homeobox protein Hox-A11, Hoxa11, HXA11_MOUSE, homeo box A11, Hox-1.9, Hoxa-11 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P31311 |
| Description: | homeo box A11 |
| Notes: | Ensembl ID: ENSMUSG00000038210; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 88 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SGHTEDKAGGSGGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQV 60 61 KIWFQNRRMKEKKINRDRLQYYSANPLL |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1ig7_A, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 3d1n_M, 1fjl_B, 1zq3_P, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 7psx_B, 1b72_A, 5hod_A, 3a01_E, 5jlw_D, 3lnq_A, 1jgg_B, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 1le8_A, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 3l1p_A, 1o4x_A, 4qtr_D, 1le8_B, 1du0_A, 1mnm_C, 1k61_B, 8g87_X |
| Binding Motifs: | UP00246A_1 waarGTCRTAAAayrk Hoxa11_DBD_1 rgTCRTwAAawt Hoxa11_DBD_2 rgymATwAAah |
| Binding Sites: | TAATAAAA AATAAAAC AATAAAAT AATTAATA ATCGTAAA ATTTACGA CAATAAAA CATAAAAA CCATAAAA CTCGTAAA GCAATAAA GTAATAAA GTCATAAA GTCATTAA GTCGTTAA TAATTAAA TCATAAAA TCATTAAA TCGTAAAA TCGTTAAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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