Transcription Factor

						

			
Accessions: SOX2_DBD (HumanTF 1.0), SOX9_DBD (HumanTF 1.0)

			
Names: SOX2, SOX2_HUMAN, SOX9, SOX9_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: P48431
Notes: Ensembl ID: ENSG00000181449; DNA-binding domain sequence; TF family: HMG; Clone source: MGC, Ensembl ID: ENSG00000125398; DNA-binding domain sequence; TF family: HMG; Clone source: MGC
Length: 112
Pfam Domains:     20-83 Domain of unknown function (DUF1898)
    23-91 HMG (high mobility group) box
   92-111 SOX transcription factor
Sequence: 
(in bold interface residues)		   1 MAGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAE   60
  61 WKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGG
Interface Residues: 25, 28, 30, 31, 32, 34, 38, 42, 49, 50, 51, 54, 92, 96
3D-footprint Homologues: 3tmm_A, 7m5w_A, 2gzk_A, 3u2b_C, 1j5n_A, 2lef_A, 4s2q_D, 1o4x_B, 3f27_D, 4y60_C, 1qrv_A, 1hry_A, 1ckt_A, 7zie_A
Binding Motifs: SOX2_DBD_1 rAACAATGkyAKTGTTm
SOX2_DBD_2 aTGAATGkyATTCAk
SOX2_DBD_3 rATCAATGkyATTGAtr
SOX9_DBD raACAATrg
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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