Transcription Factor
| Accessions: | 2pua_A (3D-footprint 20231221) |
| Names: | HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor, PURINE REPRESSOR, PURR_ECOLI |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P0ACP7 |
| Length: | 339 |
| Pfam Domains: | 2-47 Bacterial regulatory proteins, lacI family 59-324 Periplasmic binding proteins and sugar binding domain of LacI family 61-307 Periplasmic binding protein domain 170-330 Periplasmic binding protein-like domain |
| Sequence: (in bold interface residues) | 1 ATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKS 60 61 IGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLV 120 121 MCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREI 180 181 GVIPGPLEANTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPT 240 241 AVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETA 300 301 FNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR |
| Interface Residues: | 3, 4, 13, 14, 15, 16, 18, 19, 25, 26, 27, 50, 53, 54 |
| 3D-footprint Homologues: | 7ce1_D, 1efa_B, 3oqm_C, 1l1m_B, 1jft_A, 1zvv_A |
| Binding Motifs: | 2pua_A CGCanACg |
| Binding Sites: | 2pua_B |
| Publications: | Schumacher M.A, Choi K.Y, Zalkin H, Brennan R.G. Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science (New York, N.Y.) 266:763-70 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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