Transcription Factor

						

			
Accessions: 5e24_E (3D-footprint 20231221)

			
Names: J kappa-recombination signal-binding protein, RBP-J kappa, SUH_DROME, Suppressor of hairless protein
Organisms: Drosophila melanogaster
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P28159
Length: 424
Pfam Domains:    24-154 LAG1, DNA binding
  155-304 Beta-trefoil DNA-binding domain
  341-420 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 HIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSGWTRRY   60
  61 EEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSVK  120
 121 MFYGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLH  180
 181 VEGGHFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLII  240
 241 RKVDKQMALLEADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMIND  300
 301 GACWTIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQV  360
 361 WFGDVEAETMYRCTETLLCVVPEISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTY  420
 421 TPEP
Interface Residues: 36, 37, 39, 41, 57, 59, 61, 62, 65, 69, 86, 87, 88, 90, 141, 142, 145, 170, 171, 172
3D-footprint Homologues: 3iag_C, 5e24_E, 3brd_A, 7w1m_H
Binding Motifs: 5e24_E tCCCAc
Binding Sites: 5e24_H
5e24_G
			
Publications: Yuan Z, Praxenthaler H, Tabaja N, Torella R, Preiss A, Maier D, Kovall RA. Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster. PLoS Biol : (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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