Transcription Factor
| Accessions: | TFE2_HUMAN (HOCOMOCO 10), P15923 (JASPAR 2024) |
| Names: | bHLHb21, Class B basic helix-loop-helix protein 21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, TCF-3, TFE2_HUMAN, Transcription factor 3, Transcription factor E2-alpha, Transcription factor ITF-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 654 |
| Pfam Domains: | 550-603 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWG 60 61 SGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGGKSGERGAYASFGRDAGVGGL 120 121 TQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL 180 181 PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPML 240 241 GGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGAT 300 301 YGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP 360 361 QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLP 420 421 GHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPD 480 481 SYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSPDEDEDDLLPP 540 541 EQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQAVSVIL 600 601 NLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGLSEAHNPAGHM |
| Interface Residues: | 551, 554, 555, 557, 558, 559, 561, 562 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 6g1l_A, 6od3_F, 7d8t_A, 4h10_B, 2ql2_D, 2ypa_B, 2ql2_A |
| Binding Motifs: | MA0522.2 mrCACCTGbd TFE2_HUMAN.H10MO.C|M01573 amCAGATGkyc MA0091.1 mgAmCAKMTGkT MA0522.3 svCACCTGCss MA0522.4 CACCTGC |
| Binding Sites: | MA0091.1.1 MA0091.1.10 MA0091.1.11 MA0091.1.12 MA0091.1.13 MA0091.1.14 MA0091.1.15 MA0091.1.16 MA0091.1.17 MA0091.1.18 MA0091.1.19 MA0091.1.2 MA0091.1.20 MA0091.1.3 MA0091.1.4 MA0091.1.5 MA0091.1.6 MA0091.1.7 MA0091.1.8 MA0091.1.9 MA0522.3.11 MA0522.3.14 MA0522.3.1 MA0522.3.10 / MA0522.3.7 MA0522.3.11 MA0522.3.12 MA0522.3.13 / MA0522.3.15 / MA0522.3.16 MA0522.3.14 / MA0522.3.8 MA0522.3.17 / MA0522.3.9 MA0522.3.10 / MA0522.3.18 MA0522.3.19 MA0522.3.2 MA0522.3.20 MA0522.3.3 MA0522.3.2 / MA0522.3.4 MA0522.3.3 / MA0522.3.5 MA0522.3.4 / MA0522.3.6 MA0522.3.5 / MA0522.3.7 MA0522.3.8 MA0522.3.6 / MA0522.3.9 MA0522.3.12 MA0522.3.13 MA0522.3.15 MA0522.3.16 MA0522.3.17 MA0522.3.18 MA0522.3.19 MA0522.3.20 MA0522.4.1 / MA0522.4.13 MA0522.4.10 / MA0522.4.14 / MA0522.4.15 / MA0522.4.16 / MA0522.4.19 / MA0522.4.3 / MA0522.4.5 / MA0522.4.6 / MA0522.4.9 MA0522.4.11 / MA0522.4.20 MA0522.4.12 MA0522.4.17 MA0522.4.18 MA0522.4.2 / MA0522.4.7 MA0522.4.4 MA0522.4.8 |
| Publications: | Hsu H.-L., Huang L., Tsan J. T., Funk W., Wright W. E., Hu J.-S., Kingston R. E., Baer R. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol. Cell. Biol. 14:1256-1265 (1994). [Pubmed] Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed] |
| Related annotations: | PaperBLAST |
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