Transcription Factor

						

			
Accessions: TCF7L1_full (HumanTF 1.0)

			
Names: Fragment, Putative uncharacterized protein TCF7L1, Q53T87_HUMAN, TCF7L1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q53T87
Notes: Ensembl ID: ENSG00000152284; Full protein sequence; TF family: HMG; Clone source: hORFeome
Length: 589
Pfam Domains:    26-250 N-terminal CTNNB1 binding
  346-413 HMG (high mobility group) box
  347-405 Domain of unknown function (DUF1898)
Sequence: 
(in bold interface residues)		   1 MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQR   60
  61 DLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYP  120
 121 GYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVP  180
 181 VVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGA  240
 241 VGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGL  300
 301 PTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEM  360
 361 RAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYG  420
 421 KKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPA  480
 481 TPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPP  540
 541 LLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH*
Interface Residues: 348, 351, 353, 354, 357, 361, 372, 373, 374, 377, 415, 417, 418, 419, 422
3D-footprint Homologues: 3f27_D, 7m5w_A, 1o4x_B, 3u2b_C, 2gzk_A, 4s2q_D, 2lef_A, 4y60_C, 1j5n_A, 1hry_A, 8a5p_G
Binding Motifs: TCF7L1_full AAAGATCAAAGG
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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