Transcription Factor
| Accessions: | T084680_1.02 (CISBP 1.02), GATA6_HUMAN (HOCOMOCO 10), Q92908 (JASPAR 2024) |
| Names: | GATA6, T084680_1.02;, GATA-binding factor 6, GATA6_HUMAN, Transcription factor GATA-6 |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:GATA |
| Length: | 595 |
| Pfam Domains: | 147-381 GATA-type transcription activator, N-terminal 390-423 GATA zinc finger 444-477 GATA zinc finger |
| Sequence: (in bold interface residues) | 1 MALTDGGWCLPKRFGAAGADASDSRAFPAREPSTPPSPISSSSSSCSRGGERGPGGASNC 60 61 GTPQLDTEAAAGPPARSLLLSSYASHPFGAPHGPSAPGVAGPGGNLSSWEDLLLFTDLDQ 120 121 AATASKLLWSSRGAKLSPFAPEQPEEMYQTLAALSSQGPAAYDGAPGGFVHSAAAAAAAA 180 181 AAASSPVYVPTTRVGSMLPGLPYHLQGSGSGPANHAGGAGAHPGWPQASADSPPYGSGGG 240 241 AAGGGAAGPGGAGSAAAHVSARFPYSPSPPMANGAAREPGGYAAAGSGGAGGVSGGGSSL 300 301 AAMGGREPQYSSLSAARPLNGTYHHHHHHHHHHPSPYSPYVGAPLTPAWPAGPFETPVLH 360 361 SLQSRAGAPLPVPRGPSADLLEDLSESRECVNCGSIQTPLWRRDGTGHYLCNACGLYSKM 420 421 NGLSRPLIKPQKRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRP 480 481 LAMKKEGIQTRKRKPKNINKSKTCSGNSNNSIPMTPTSTSSNSDDCSKNTSPTTQPTASG 540 541 AGAPVMTGAGESTNPENSELKYSGQDGLYIGVSLASPAEVTSSVRPDSWCALALA |
| Interface Residues: | 399, 400, 402, 412, 416, 453, 454, 456, 466, 470, 471, 474, 491, 493, 494 |
| 3D-footprint Homologues: | 4hc9_A, 3vd6_C, 1gat_A, 3dfx_B, 4gat_A |
| Binding Motifs: | M3334_1.02 awhGATwags GATA6_HUMAN.H10MO.B|M01178 ddmWGATAAGawar MA1104.1 wwvAGATAAGawa MA1104.2 wwwTCTTATCTtw MA1104.3 TCTTATCT |
| Binding Sites: | MA1104.3.6 MA1104.3.14 MA1104.3.3 / MA1104.3.9 MA1104.1.1 MA1104.1.10 MA1104.1.11 MA1104.1.12 MA1104.1.13 MA1104.1.14 MA1104.1.15 MA1104.1.16 MA1104.1.17 MA1104.1.18 MA1104.1.19 MA1104.1.2 MA1104.1.20 MA1104.1.3 MA1104.1.4 MA1104.1.5 MA1104.1.6 MA1104.1.7 MA1104.1.8 MA1104.1.9 MA1104.2.1 MA1104.2.10 / MA1104.2.6 MA1104.2.11 MA1104.2.12 / MA1104.2.7 MA1104.2.13 MA1104.2.14 / MA1104.2.8 MA1104.2.15 MA1104.2.16 / MA1104.2.9 MA1104.2.10 / MA1104.2.17 MA1104.2.11 / MA1104.2.18 MA1104.2.12 / MA1104.2.19 MA1104.2.2 MA1104.2.20 MA1104.2.1 / MA1104.2.3 MA1104.2.4 MA1104.2.2 / MA1104.2.5 MA1104.2.3 / MA1104.2.6 MA1104.2.4 / MA1104.2.7 MA1104.2.5 / MA1104.2.8 MA1104.2.9 MA1104.2.13 MA1104.2.14 MA1104.2.15 MA1104.2.16 MA1104.2.17 MA1104.2.18 MA1104.2.19 MA1104.2.20 MA1104.3.18 / MA1104.3.2 / MA1104.3.20 MA1104.3.11 / MA1104.3.4 / MA1104.3.8 MA1104.3.10 / MA1104.3.17 / MA1104.3.7 MA1104.3.1 MA1104.3.12 MA1104.3.13 MA1104.3.15 MA1104.3.16 MA1104.3.19 MA1104.3.5 |
| Publications: | Merika M., Orkin S. H. DNA-binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13:3999-4010 (1993). [Pubmed] Shaw-White J. R., Bruno M. D., Whitsett J. A. GATA-6 activates transcription of thyroid transcription factor-1.. J. Biol. Chem. 274:2658-2664 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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