Transcription Factor
Accessions: | 1pzu_B (3D-footprint 20231221), 1pzu_H (3D-footprint 20231221), 1pzu_I (3D-footprint 20231221), 1pzu_M (3D-footprint 20231221) |
Names: | NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q13469 |
Length: | 276 |
Pfam Domains: | 12-172 Rel homology domain (RHD) 187-273 IPT/TIG domain |
Sequence: (in bold interface residues) | 1 WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQI 60 61 FIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGI 120 121 LKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQELPMVER 180 181 QDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI 240 241 PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV |
Interface Residues: | 23, 25, 26, 28, 29, 32, 122, 139, 168, 170, 173, 199, 200, 232, 262, 263 |
3D-footprint Homologues: | 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A |
Binding Motifs: | 1pzu_B tGGAa 1pzu_BHIM TCCAnnnnGGAAnTTCCAnnnAGGAA |
Binding Sites: | 1pzu_T 1pzu_W 1pzu_X 1pzu_Y |
Publications: | Jin L, Sliz P, Chen L, Macián F, Rao A, Hogan P.G, Harrison S.C. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nature structural biology 10:807-11 (2003). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.