Transcription Factor

						

			
Accessions: 1pzu_B (3D-footprint 20231221), 1pzu_H (3D-footprint 20231221), 1pzu_I (3D-footprint 20231221), 1pzu_M (3D-footprint 20231221)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 276
Pfam Domains:    12-172 Rel homology domain (RHD)
  187-273 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQI   60
  61 FIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGI  120
 121 LKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQELPMVER  180
 181 QDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI  240
 241 PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 23, 25, 26, 28, 29, 32, 122, 139, 168, 170, 173, 199, 200, 232, 262, 263
3D-footprint Homologues: 1a66_A, 1imh_C, 1p7h_L, 2o61_A, 1nfk_A
Binding Motifs: 1pzu_B tGGAa
1pzu_BHIM TCCAnnnnGGAAnTTCCAnnnAGGAA
Binding Sites: 1pzu_T
1pzu_W
1pzu_X
1pzu_Y
			
Publications: Jin L, Sliz P, Chen L, Macián F, Rao A, Hogan P.G, Harrison S.C. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nature structural biology 10:807-11 (2003). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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