Transcription Factor

						

			
Accessions: 1pzu_B (3D-footprint 20231221), 1pzu_H (3D-footprint 20231221), 1pzu_I (3D-footprint 20231221), 1pzu_M (3D-footprint 20231221)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 276
Pfam Domains:    12-172 Rel homology domain (RHD)
  187-273 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQI   60
  61 FIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGI  120
 121 LKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQELPMVER  180
 181 QDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEI  240
 241 PEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 23, 25, 26, 28, 29, 32, 122, 139, 168, 170, 173, 199, 200, 232, 262, 263
3D-footprint Homologues: 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A
Binding Motifs: 1pzu_B tGGAa
1pzu_BHIM TCCAnnnnGGAAnTTCCAnnnAGGAA
Binding Sites: 1pzu_T
1pzu_W
1pzu_X
1pzu_Y
			
Publications: Jin L, Sliz P, Chen L, Macián F, Rao A, Hogan P.G, Harrison S.C. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nature structural biology 10:807-11 (2003). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.