Transcription Factor

Accessions: 1fos_E (3D-footprint 20231221)
Names: Cellular oncogene fos, FOS_HUMAN, G0/G1 switch regulatory protein 7, P55-C-FOS PROTO-ONCOGENE PROTEIN, Proto-oncogene c-Fos
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P01100
Length: 60
Pfam Domains: 1-56 bZIP transcription factor
1-51 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 KRRIRRERNKMAAAKSRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILA 60
Interface Residues: 5, 6, 9, 10, 12, 13, 16, 17
3D-footprint Homologues: 2wt7_A, 7x5e_F, 6mg1_B, 1nwq_C, 2dgc_A, 5vpe_C, 4eot_A, 5t01_B
Binding Motifs: 1fos_E AGTCA
1fos_EF TgACTca
Binding Sites: 1fos_A
1fos_B
Publications: Glover J. N. M., Harrison S. C. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature 373:257-261 (1995). [Pubmed]
Related annotations: PaperBLAST

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