Transcription Factor
| Accessions: | BHLHA15_DBD (HumanTF 1.0), BHLHA15_TF2 (HumanTF2 1.0), BHLHA15 (HT-SELEX2 May2017) |
| Names: | BHA15_HUMAN, BHLHA15, bHLHb8, Class A basic helix-loop-helix protein 15, Class B basic helix-loop-helix protein 8, MIST-1, Muscle, intestine and stomach expression 1, ENSG00000180535 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q7RTS1 |
| Notes: | Ensembl ID: ENSG00000180535; DNA-binding domain sequence; TF family: bHLH; Clone source: Gene synthesis, Ensembl ID: ENSG00000180535; Construct type: TF2(3xFLAG); TF family: bHLH; Clone source: Jolma et al. 2013, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 115 |
| Pfam Domains: | 28-79 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 AARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRAD 60 61 KKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGA |
| Interface Residues: | 29, 31, 32, 33, 35, 36, 37, 39, 40, 63, 65, 87 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 1an4_A, 6od3_F, 5i50_B, 7ssa_L, 5eyo_A, 2ql2_A, 2ql2_D, 2ypa_B, 4h10_A, 5nj8_D, 5v0l_A, 5gnj_I, 7xhv_B, 7xi3_B, 3zdb_A |
| Binding Motifs: | BHLHA15_DBD ACCATATGkt ARNTL_BHLHA15 rtCACGTGMacmCATATGgk CLOCK_BHLHA15 wCAYGTGkcyarCAyrTGs ETV2_BHLHA15 rsCGGAAmCATATGk FLI1_BHLHA15 wcCGGAAACATATGk RFX3_BHLHA15 TrGCaACgavCATATGkt BHLHA15_3 rmCATATGky BHLHA15_4 avCAGCTGyy BHLHA15_methyl_1 rmCATATGky BHLHA15_methyl_2 amCAGCTGkt |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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