Transcription Factor

						

			
Accessions: 4yo2_A (3D-footprint 20231221)

			
Names: E2F-8, E2F8_HUMAN, Transcription factor E2F8
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: A0AVK6
Length: 186
Pfam Domains:      4-73 E2F/DP family winged-helix DNA-binding domain
  106-177 E2F/DP family winged-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 QPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHM   60
  61 VSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKNSRKDKSLRVMSQKFVM  120
 121 LFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTE  180
 181 ERGRKP
Interface Residues: 4, 42, 44, 45, 46, 47, 49, 155, 158, 159, 161
3D-footprint Homologues: 1cf7_A, 4yo2_A, 1cf7_B
Binding Motifs: 4yo2_A TGGCGGRr
Binding Sites: 4yo2_C
4yo2_D
			
Publications: Morgunova E, Yin Y, Jolma A, Dave K, Schmierer B, Popov A, Eremina N, Nilsson L, Taipale J. Structural insights into the DNA-binding specificity of E2F family transcription factors. Nat Commun : (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.