Transcription Factor

Accessions: 1p7h_L (3D-footprint 20231221), 1p7h_N (3D-footprint 20231221)
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 286
Pfam Domains: 18-178 Rel homology domain (RHD)
197-283 IPT/TIG domain
Sequence:
(in bold interface residues)
1 SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENK 60
61 PLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRAT 120
121 IDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQR 180
181 SAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDK 240
241 SQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 29, 31, 32, 34, 35, 38, 128, 145, 178, 179, 180, 209, 210, 242, 272, 273
3D-footprint Homologues: 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A
Binding Motifs: 1p7h_L GGAa
1p7h_LN TTCCnAnnnGGGA
Binding Sites: 1p7h_A
1p7h_B
1p7h_C
1p7h_D
Publications: Giffin M.J, Stroud J.C, Bates D.L, von Koenig K.D, Hardin J, Chen L. Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element. Nature structural biology 10:800-6 (2003). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.