Transcription Factor
Accessions: | 1p7h_L (3D-footprint 20231221), 1p7h_N (3D-footprint 20231221) |
Names: | NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q13469 |
Length: | 286 |
Pfam Domains: | 18-178 Rel homology domain (RHD) 197-283 IPT/TIG domain |
Sequence: (in bold interface residues) | 1 SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENK 60 61 PLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRAT 120 121 IDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQR 180 181 SAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDK 240 241 SQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV |
Interface Residues: | 29, 31, 32, 34, 35, 38, 128, 145, 178, 179, 180, 209, 210, 242, 272, 273 |
3D-footprint Homologues: | 1p7h_L, 1a66_A, 1imh_C, 2o61_A, 1nfk_A |
Binding Motifs: | 1p7h_L GGAa 1p7h_LN TTCCnAnnnGGGA |
Binding Sites: | 1p7h_A 1p7h_B 1p7h_C 1p7h_D |
Publications: | Giffin M.J, Stroud J.C, Bates D.L, von Koenig K.D, Hardin J, Chen L. Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element. Nature structural biology 10:800-6 (2003). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.