Transcription Factor

						

			
Accessions: 1p7h_L (3D-footprint 20231221), 1p7h_N (3D-footprint 20231221)

			
Names: NF-ATc2, NF-ATp, NFAC2_HUMAN, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q13469
Length: 286
Pfam Domains:    18-178 Rel homology domain (RHD)
  197-283 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 SSVPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENK   60
  61 PLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRAT  120
 121 IDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPIECSQR  180
 181 SAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDK  240
 241 SQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
Interface Residues: 29, 31, 32, 34, 35, 38, 128, 145, 178, 179, 180, 209, 210, 242, 272, 273
3D-footprint Homologues: 1imh_C, 1p7h_L, 1a66_A, 2o61_A, 1nfk_A
Binding Motifs: 1p7h_L GGAa
1p7h_LN TTCCnAnnnGGGA
Binding Sites: 1p7h_A
1p7h_B
1p7h_C
1p7h_D
			
Publications: Giffin M.J, Stroud J.C, Bates D.L, von Koenig K.D, Hardin J, Chen L. Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element. Nature structural biology 10:800-6 (2003). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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