Transcription Factor
| Accessions: | LEF1_DBD (HumanTF 1.0), LEF1 (HT-SELEX2 May2017) |
| Names: | LEF-1, LEF1, LEF1_HUMAN, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha, ENSG00000138795 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q9UJU2 |
| Notes: | Ensembl ID: ENSG00000138795; DNA-binding domain sequence; TF family: HMG; Clone source: MGC, TF family: HMG experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: HMG experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 109 |
| Pfam Domains: | 16-79 Domain of unknown function (DUF1898) 21-88 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 LMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWH 60 61 ALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESA |
| Interface Residues: | 23, 26, 28, 29, 32, 36, 47, 48, 49, 52, 90, 92, 94, 97, 99, 100, 101, 104 |
| 3D-footprint Homologues: | 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1hry_A |
| Binding Motifs: | LEF1_DBD aAAGATCAAAGgrww LEF1_2 asATCAAAg LEF1_4 AsATCAAAG LEF1_methyl_1 AsATCAAAG LEF1_methyl_3 AsATCAAAG |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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