Transcription Factor

						

			
Accessions: 3brg_C (3D-footprint 20231221)

			
Names: J kappa-recombination signal-binding protein, RBP-J kappa, Recombining binding protein suppressor of hairless, SUH_MOUSE
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P31266
Length: 414
Pfam Domains:    21-146 LAG1, DNA binding
  151-294 Beta-trefoil DNA-binding domain
  322-410 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQ   60
  61 MERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMF  120
 121 YGNSDDIGVFLSKRIKVISKPSKKKLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGG  180
 181 NFHASSQQWGAFYIHLLDDDETVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALL  240
 241 DADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTD  300
 301 KAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETM  360
 361 YRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGVIYSTSLTFTYTPEP
Interface Residues: 34, 37, 39, 139, 140, 143, 166, 167, 168
3D-footprint Homologues: 3brd_A, 3iag_C, 5e24_E
Binding Motifs: 3brg_C TTCCCACA
Binding Sites: 3brg_B
3brg_A
			
Publications: Friedmann D.R, Wilson J.J, Kovall R.A. RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. The Journal of biological chemistry 283:14781-91 (2008). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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