Transcription Factor
Accessions: | 4nnu_B (3D-footprint 20231221) |
Names: | Mitochondrial transcription factor 1, MtTF1, mtTFA, TCF-6, TFAM_HUMAN, Transcription factor 6, Transcription factor 6-like 2, Transcription factor A, mitochondrial |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | Q00059 |
Length: | 192 |
Pfam Domains: | 7-75 HMG (high mobility group) box 7-69 Domain of unknown function (DUF1898) 111-172 Domain of unknown function (DUF1898) 112-175 HMG (high mobility group) box |
Sequence: (in bold interface residues) | 1 SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAY 60 61 RAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYN 120 121 VYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMI 180 181 EVGRKDLLRRTI |
Interface Residues: | 9, 12, 14, 15, 18, 22, 33, 34, 35, 38, 96, 97, 98, 100, 103, 104, 114, 119, 120, 123, 127, 135, 136, 139 |
3D-footprint Homologues: | 4y60_C, 1o4x_B, 3tmm_A, 6jrp_D, 1qrv_A, 2gzk_A, 3u2b_C, 1j5n_A, 3f27_D, 3tq6_B, 1hry_A, 1ckt_A, 7zie_A |
Binding Motifs: | 4nnu_AB TCCCGnnnnnnAACTTnnnnGnTCCCnnnnnnnAACTT 4nnu_B GnTCCCnnnnnnnAACTT |
Publications: | Ngo H.B, Lovely G.A, Phillips R, Chan D.C. Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nature communications 5:3077 (2014). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.