Transcription Factor

						

			
Accessions: 4nnu_B (3D-footprint 20231221)

			
Names: Mitochondrial transcription factor 1, MtTF1, mtTFA, TCF-6, TFAM_HUMAN, Transcription factor 6, Transcription factor 6-like 2, Transcription factor A, mitochondrial
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q00059
Length: 192
Pfam Domains:      7-75 HMG (high mobility group) box
     7-69 Domain of unknown function (DUF1898)
  111-172 Domain of unknown function (DUF1898)
  112-175 HMG (high mobility group) box
Sequence: 
(in bold interface residues)		   1 SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAY   60
  61 RAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYN  120
 121 VYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMI  180
 181 EVGRKDLLRRTI
Interface Residues: 9, 12, 14, 15, 18, 22, 33, 34, 35, 38, 96, 97, 98, 100, 103, 104, 114, 119, 120, 123, 127, 135, 136, 139
3D-footprint Homologues: 2gzk_A, 3u2b_C, 1j5n_A, 3f27_D, 4y60_C, 1o4x_B, 3tmm_A, 6jrp_D, 1qrv_A, 3tq6_B, 1hry_A, 7zie_A, 1ckt_A
Binding Motifs: 4nnu_AB TCCCGnnnnnnAACTTnnnnGnTCCCnnnnnnnAACTT
4nnu_B GnTCCCnnnnnnnAACTT
			
Publications: Ngo H.B, Lovely G.A, Phillips R, Chan D.C. Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nature communications 5:3077 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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