Transcription Factor
| Accessions: | TFAP2A (HT-SELEX2 May2017) |
| Names: | ENSG00000137203, TFAP2A |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: TFAP experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: TFAP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 439 |
| Pfam Domains: | 209-415 Transcription factor AP-2 |
| Sequence: (in bold interface residues) | 1 MKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYF 60 61 PPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQL 120 121 SGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKG 180 181 PVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRL 240 241 SPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAV 300 301 HLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLLAQDRSP 360 361 LGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNP 420 421 NSHTDNNAKSSDKEEKHRK |
| Interface Residues: | 224, 258, 259 |
| 3D-footprint Homologues: | 8j0k_B |
| Binding Motifs: | TFAP2A_2 yGCCtsaGGCr TFAP2A_methyl_1 wGCCTsAGGCw |
| Related annotations: | PaperBLAST |
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