Transcription Factor
| Accessions: | SOX2_HUMAN (HOCOMOCO 10), P48431 (JASPAR 2024) |
| Names: | SOX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 317 |
| Pfam Domains: | 38-101 Domain of unknown function (DUF1898) 41-109 HMG (high mobility group) box 110-200 SOX transcription factor |
| Sequence: (in bold interface residues) | 1 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMA 60 61 QENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLM 120 121 KKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGY 180 181 PQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSM 240 241 GSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQS 300 301 GPVPGTAINGTLPLSHM |
| Interface Residues: | 43, 46, 48, 49, 50, 52, 56, 67, 68, 69, 72, 110, 114 |
| 3D-footprint Homologues: | 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 1ckt_A, 1hry_A, 3tq6_B, 7zie_A |
| Binding Motifs: | MA1962.1 mATTWrCATmACAAWrg SOX2_HUMAN.H10MO.B|M01516 cYwTTGTyaTgcaaAt MA0143.4 wwACAATGgww MA0143.5 ACAATGg |
| Binding Sites: | MA0143.4.4 MA0143.4.1 MA0143.4.10 MA0143.4.11 / MA0143.4.7 MA0143.4.12 / MA0143.4.8 MA0143.4.13 MA0143.4.14 MA0143.4.15 / MA0143.4.9 MA0143.4.10 / MA0143.4.16 MA0143.4.17 MA0143.4.11 / MA0143.4.18 MA0143.4.12 / MA0143.4.19 MA0143.4.1 / MA0143.4.2 MA0143.4.13 / MA0143.4.20 MA0143.4.3 MA0143.4.2 / MA0143.4.5 MA0143.4.3 / MA0143.4.6 MA0143.4.4 / MA0143.4.7 MA0143.4.8 MA0143.4.5 / MA0143.4.9 MA0143.4.14 MA0143.4.15 MA0143.4.16 MA0143.4.17 MA0143.4.18 MA0143.4.19 MA0143.4.20 MA0143.4.6 MA0143.5.1 / MA0143.5.14 / MA0143.5.15 / MA0143.5.17 / MA0143.5.2 / MA0143.5.20 / MA0143.5.8 / MA0143.5.9 MA0143.5.10 / MA0143.5.11 / MA0143.5.12 / MA0143.5.16 MA0143.5.13 / MA0143.5.5 / MA0143.5.7 MA0143.5.18 MA0143.5.19 MA0143.5.3 / MA0143.5.4 MA0143.5.6 |
| Publications: | Maruyama M., Ichisaka T., Nakagawa M., Yamanaka S. Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells.. J. Biol. Chem. 280:24371-24379 (2005). [Pubmed] Malik V, Zimmer D, Jauch R. Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming. Cell Mol Life Sci 75:1587-1612 (2018). [Pubmed] |
| Related annotations: | PaperBLAST |
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