Transcription Factor
| Accessions: | 4h10_B (3D-footprint 20231221) |
| Names: | bHLHe8, Circadian locomoter output cycles protein kaput, Class E basic helix-loop-helix protein 8, CLOCK_HUMAN, EC 2.3.1.48, hCLOCK |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | O15516 |
| Length: | 63 |
| Pfam Domains: | 5-53 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLPGNARKMDKSTVLQKSIDFLRKHKEITAW 60 61 LEH |
| Interface Residues: | 4, 6, 8, 9, 10, 12, 13, 15, 16, 17, 21, 40 |
| 3D-footprint Homologues: | 4zpr_B, 1a0a_B, 4zpk_B, 7ssa_L, 7xq5_A, 6g1l_A, 7xhv_B, 5nj8_D, 4h10_A, 8osl_O, 7d8t_A, 7xi3_A, 5v0l_A, 4h10_B, 7f2f_B, 5eyo_A, 1am9_A, 7xi3_B, 4zpk_A, 2ql2_A, 8osl_P, 5nj8_C, 5v0l_B |
| Binding Motifs: | 4h10_AB TCACGtG 4h10_B CAcg |
| Binding Sites: | 4h10_C 4h10_D |
| Publications: | Wang Z, Wu Y, Li L, Su X.D. Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA. Cell research : (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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