Transcription Factor
| Accessions: | MYCN_MOUSE (HOCOMOCO 10), P03966 (JASPAR 2024) |
| Names: | MYCN_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P03966 |
| Length: | 462 |
| Pfam Domains: | 9-370 Myc amino-terminal region 380-432 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MPSCTASTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPP 60 61 LSPSRAFPEHSPEPSNWATEMLLPEADLWGNPAEEDAFGLGGLGGLTPNPVILQDCMWSG 120 121 FSAREKLERAVNEKLQHGHGPPGVSSACSAPGVGASSPGGRALGGSSSASHTGATLPTDL 180 181 SHPAAECVDPAVVFPFPVNKRESASVPAAPTSAPATSAAVTSVSVPATAPVAAPARAGGR 240 241 PASSGEAKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNNKAVTTFTITVR 300 301 PKTSALGLGRAQPGELILKRCVPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSV 360 361 VPAKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVI 420 421 LKKATEYVHALQANEHQLLLEKEKLQARQQQLLKKIEHARTC |
| Interface Residues: | 384, 385, 387, 388, 391, 392, 396, 417 |
| 3D-footprint Homologues: | 8ia3_B, 5v0l_A, 7ssa_L, 7d8t_A, 7xi3_A, 7f2f_B, 7xq5_A, 7rcu_E |
| Binding Motifs: | MA0104.2 msCACGTGGc MYCN_MOUSE.H10MO.B|M01218 cCACGTGs MA0104.1 CACGTG MA0104.3 rCCACGTG |
| Binding Sites: | MA0104.1.1 MA0104.1.10 MA0104.1.11 MA0104.1.12 MA0104.1.13 MA0104.1.14 MA0104.1.15 MA0104.1.16 MA0104.1.17 MA0104.1.18 MA0104.1.19 MA0104.1.2 MA0104.1.20 MA0104.1.3 MA0104.1.4 MA0104.1.5 MA0104.1.6 MA0104.1.7 MA0104.1.8 MA0104.1.9 MA0104.2.1 MA0104.2.10 MA0104.2.11 MA0104.2.12 MA0104.2.13 MA0104.2.14 MA0104.2.15 MA0104.2.16 MA0104.2.17 MA0104.2.18 MA0104.2.19 MA0104.2.2 MA0104.2.20 MA0104.2.3 MA0104.2.4 MA0104.2.5 MA0104.2.6 MA0104.2.7 MA0104.2.8 MA0104.2.9 MA0104.3.1 MA0104.3.10 MA0104.3.11 MA0104.3.12 MA0104.3.13 MA0104.3.14 MA0104.3.15 MA0104.3.16 MA0104.3.17 MA0104.3.18 MA0104.3.19 MA0104.3.2 MA0104.3.20 MA0104.3.3 MA0104.3.4 MA0104.3.5 MA0104.3.6 MA0104.3.7 MA0104.3.8 MA0104.3.9 |
| Publications: | Alex R., Soezeri O., Meyer S., Dildrop R. Determination of the DNA sequence recognized by the bHLH-zip domain of the N-Myc protein. Nucleic Acids Res. 20:2257-2263 (1992). [Pubmed] Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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