Transcription Factor
| Accessions: | DLX2_DBD (HumanTF 1.0), DLX2_TF2 (HumanTF2 1.0) |
| Names: | DLX2, DLX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | Q07687 |
| Notes: | Ensembl ID: ENSG00000115844; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000115844; Construct type: TF2(3xFLAG); TF family: Homeodomain; Clone source: Jolma et al. 2013 |
| Length: | 188 |
| Pfam Domains: | 3-83 Homeobox protein distal-less-like N terminal 104-160 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYD 60 61 LGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQR 120 121 RFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPP 180 181 CASPPVSA |
| Interface Residues: | 104, 105, 106, 107, 145, 146, 148, 149, 152, 153, 156, 157, 160 |
| 3D-footprint Homologues: | 5zjt_E, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 3a01_E, 7psx_B, 1au7_A, 5hod_A, 3lnq_A, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1jgg_B, 5flv_I, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 1o4x_A, 8g87_X, 4qtr_D, 1k61_B, 4xrm_B, 1puf_B, 1du0_A, 3l1p_A |
| Binding Motifs: | DLX2_DBD syaATTAm ERF_DLX2_1 rsmGGAwrtsrvymaTTA ERF_DLX2_2 rsmGGAwrtsrvymaTTa ETV2_DLX2_1 acCGGAWrTwrmbyAATTR ETV2_DLX2_2 rsMGGAAryvvsyaATTA ETV5_DLX2 rsCGGAwrtvrsymATTA FLI1_DLX2_1 rsMGGAAryaaTtA FLI1_DLX2_2 rvmGGAArtsvsyaaTtar FLI1_DLX2_2_3 ACCGGAArTgrsyAATTA GCM2_DLX2 rTrcGGGywadwtAATtr MEIS1_DLX2 tGACArswTAATtr MGA_DLX2_1 rGGTGhTAATTr MGA_DLX2_2 syAATTAwaGGTGyGA POU2F1_DLX2_1 tgAATATkcaTmCAcTAATTG POU2F1_DLX2_2 tGmATATkCahwmkTAATTr POU2F1_DLX2_2_3 wTwTGCRwAkyYAATtr TEAD4_DLX2_1 rmATwcyargyaATTA TEAD4_DLX2_2 rCATwCyacwryAATTA TEAD4_DLX2_2_3 rmATwcywyssTAATtr TEAD4_DLX2_2_3_4 ggwATGtTAATkr TEAD4_DLX2_2_3_4_5 crCATwCCryvmTAATtrc TEAD4_DLX2_2_3_4_5_6 crCATwCCrvsyaATTA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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