Transcription Factor

						

			
Accessions: SOX2_full (HumanTF 1.0), SOX2_TF1 (HumanTF2 1.0), SOX2_TF2 (HumanTF2 1.0)

			
Names: SOX2, SOX2_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P48431
Notes: Ensembl ID: ENSG00000181449; Full protein sequence; TF family: HMG; Clone source: hORFeome, Ensembl ID: ENSG00000181449; Construct type: TF1(SBP); TF family: HMG; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000181449; Construct type: TF2(3xFLAG); TF family: SOX; Clone source: Jolma et al. 2013
Length: 318
Pfam Domains:    38-101 Domain of unknown function (DUF1898)
   41-109 HMG (high mobility group) box
  110-200 SOX transcription factor
Sequence: 
(in bold interface residues)		   1 MYNMMETELKPPGPQQTSGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMA   60
  61 QENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLM  120
 121 KKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGY  180
 181 PQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSM  240
 241 GSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQS  300
 301 GPVPGTAINGTLPLSHM*
Interface Residues: 43, 46, 48, 49, 50, 52, 56, 67, 68, 69, 72, 110, 114
3D-footprint Homologues: 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 1ckt_A, 1hry_A, 3tq6_B, 7zie_A
Binding Motifs: SOX2_full_1 sAACAATAaCATTGTTc
SOX2_full_2 hATCAATAmCATTGATm
SOX2_full_3 aTGAATamCATTCAt
GCM1_SOX2 ATrCGGGyvyATTGTty
MEIS1_SOX2 TGACAkgtkAACAATgt
POU2F1_SOX2_1 aTTwrCATrACAAwrv
POU2F1_SOX2_2 mATTWrCATmACAAWrg
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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