Transcription Factor

						

			
Accessions: Zic3_DBD (HumanTF 1.0), UP00006A (UniPROBE 20160601)

			
Names: Zic3, ZIC3_MOUSE, Zinc finger protein of the cerebellum 3, Zinc finger protein ZIC 3
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q62521
Description: zinc finger protein of the cerebellum 3: Mus musculus zinc finger protein of the cerebellum 3, mRNA (cDNA clone IMAGE:30112694), partial cds
Notes: Ensembl ID: ENSMUSG00000067860; DNA-binding domain sequence; TF family: znfC2H2; Clone source: Hughes lab.
Length: 181
Pfam Domains:     23-41 C2H2-type zinc finger
    52-77 Zinc finger, C2H2 type
    56-77 C2H2-type zinc finger
    70-95 Zinc-finger double domain
   83-107 Zinc finger, C2H2 type
   83-107 C2H2-type zinc finger
   99-126 Zinc-finger double domain
  113-137 Zinc finger, C2H2 type
  113-137 C2H2-type zinc finger
  131-154 Zinc-finger double domain
  143-165 Zinc finger, C2H2 type
  143-163 Zinc-finger double-stranded RNA-binding
  143-163 Zinc-finger of C2H2 type
  143-165 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 PIKQELSCKWIEEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEECPRE   60
  61 GKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCEFEGC  120
 121 DRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAASSGY  180
 181 E
Interface Residues: 29, 31, 32, 35, 65, 66, 67, 68, 69, 71, 72, 76, 95, 96, 97, 98, 99, 101, 102, 103, 104, 105, 107, 108, 111, 120, 125, 126, 127, 128, 129, 130, 131, 132, 133, 136, 153, 154, 155, 156, 157, 158, 159, 160, 161
3D-footprint Homologues: 5yel_A, 6wmi_A, 5v3j_F, 1ubd_C, 7n5w_A, 1tf3_A, 7w1m_H, 8cuc_F, 8ssu_A, 4x9j_A, 5ei9_F, 2gli_A, 8ssq_A, 1tf6_A, 6ml4_A, 5kkq_D, 8h9h_G, 7eyi_G, 8gn3_A, 6e94_A, 7ysf_A, 5k5i_A, 2lt7_A, 2i13_A, 7y3l_A, 6jnm_A, 3uk3_C, 2v6e_B, 1mey_C, 5kl3_A, 6u9q_A, 2kmk_A, 7txc_E, 5und_A, 1g2f_F, 1llm_D, 6blw_A, 7y3m_I, 6a57_A, 2jpa_A, 6sjf_B, 2wbs_A, 1f2i_J, 5yj3_D, 4m9v_C, 2drp_D
Binding Motifs: UP00006A_1 smCCCCCgGGGGggt
Zic3_DBD gaCCCCCyGCTGyGm
UP00006A_2 kwdCaCAGCAkGmsa
Binding Sites: ACAGCGGG
ACCCCCCA
ACCCCCCG
ACCCCCTG
CAGCGGGG
CAGGGGGG
CCAGCGGG
CCAGGGGG
CCCCCCGC
CCCCCCGG
CCCCCGGG
CCCCCTGC
CCCCGCGG
CCCCGGGG
CGGGGGGC
GACCCCCC
GCCCCCCC
GGACCCCC
GGCCCCCC
GGGGGGTA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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