Transcription Factor

						

			
Accessions: 6od3_B (3D-footprint 20231221), 6od4_A (3D-footprint 20231221), 6od4_B (3D-footprint 20231221)

			
Names: bHLHb19, Class B basic helix-loop-helix protein 19, Immunoglobulin transcription factor 2, ITF-2, ITF2_HUMAN, SEF-2, SL3-3 enhancer factor 2, TCF-4, Transcription factor 4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P15884
Length: 61
Pfam Domains:      3-56 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 HMRRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVR   60
  61 E
Interface Residues: 4, 7, 8, 10, 11, 12, 14, 15
3D-footprint Homologues: 2ypa_A, 7z5k_B, 6od3_F, 2ql2_D, 7d8t_A, 2ypa_B, 2ql2_A, 6g1l_A
Binding Motifs: 6od4_B cgTG
6od3_ABH CACGTG
6od4_AB CACGTG
Binding Sites: 6od4_W
6od4_X
			
Publications: Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res 47:8375-8387 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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