Transcription Factor
| Accessions: | FOXC2_DBD (HumanTF 1.0), FOXC2 (HT-SELEX2 May2017) |
| Names: | Forkhead box protein C2, Forkhead-related protein FKHL14, FOXC2, FOXC2_HUMAN, Mesenchyme fork head protein 1, MFH-1 protein, Transcription factor FKH-14, ENSG00000176692 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q99958 |
| Notes: | Ensembl ID: ENSG00000176692; DNA-binding domain sequence; TF family: Forkhead; Clone source: Gene synthesis, TF family: Forkhead experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Forkhead experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 132 |
| Pfam Domains: | 18-113 Fork head domain |
| Sequence: (in bold interface residues) | 1 SYAPYHHHQPAAPKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQ 60 61 GWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVS 120 121 KEKEERAHLKEP |
| Interface Residues: | 41, 58, 60, 61, 63, 64, 65, 67, 68, 69, 71, 72, 81, 88, 109, 113 |
| 3D-footprint Homologues: | 8vfz_O, 3l2c_A, 8bzm_E, 7vox_H, 2hdc_A, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 8sro_B, 3qrf_G |
| Binding Motifs: | FOXC2_DBD_1 wrtmAATATTkAyw FOXC2_DBD_2 rTAAAyAAACA FOXC2_DBD_3 wAwrTAAAYAww FOXC2_3 bwamryMAACAm FOXC2_4 ryAAAyAAACAm FOXC2_methyl_1 ywacrymAACAw FOXC2_methyl_2 rymmAyAAACAh |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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