Transcription Factor
| Accessions: | Q9Z1J1 (JASPAR 2024) |
| Names: | HMG box transcription factor 3, mTCF-3, TCF-3, TF7L1_MOUSE, Transcription factor 7-like 1 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 584 |
| Pfam Domains: | 23-247 N-terminal CTNNB1 binding 342-409 HMG (high mobility group) box 343-400 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MPQLGGGRGGAGGGGGGSGAGATSGGDDLGANDELIPFQDEGGEEQEPSSDTASAQRDLD 60 61 EVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAEVRRPQDGAFFKGGAYPGYP 120 121 FLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQ 180 181 HPHHMHPLTPLITYSNDHFSPASPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQ 240 241 IPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFPHMVAPAHPGLPTSG 300 301 IPHPAIVSPIVKQEPAAPSLSPAVSAKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKV 360 361 VAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHAQLYPTWSARDNYGKKKK 420 421 RKREKQLSQTQSQQQIQEAEGALASKSKKPCIQYLPPEKPCDSPASSHGSALDSPATPSA 480 481 ALASPAAPAATHSEQAQPLSLTTKPEARAQLALHSAAFLSAKAAASNSSQMGSQPPLLSR 540 541 PLPLGSMPAALLTSPPTFPATLHAHQALPVLQAQPLSLVTKSAH |
| Interface Residues: | 344, 347, 349, 350, 353, 357, 368, 369, 370, 373, 411, 413, 414, 415, 418 |
| 3D-footprint Homologues: | 7m5w_A, 2gzk_A, 4s2q_D, 2lef_A, 4y60_C, 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 1hry_A, 8a5p_G |
| Binding Motifs: | PB0082.1 twwasATCAAAGgrwww PB0186.1 rgssgaawawaaaww MA0522.1 smCAGCTGCwg |
| Binding Sites: | MA0522.1.13 MA0522.1.9 MA0522.1.11 MA0522.1.12 MA0522.1.1 MA0522.1.10 MA0522.1.14 MA0522.1.15 MA0522.1.16 MA0522.1.17 MA0522.1.18 MA0522.1.19 MA0522.1.2 MA0522.1.20 MA0522.1.3 MA0522.1.4 MA0522.1.5 MA0522.1.6 MA0522.1.7 MA0522.1.8 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed] |
| Related annotations: | PaperBLAST |
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