Transcription Factor

Accessions: Q9Z1J1 (JASPAR 2024)
Names: HMG box transcription factor 3, mTCF-3, TCF-3, TF7L1_MOUSE, Transcription factor 7-like 1
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 584
Pfam Domains: 23-247 N-terminal CTNNB1 binding
342-409 HMG (high mobility group) box
343-400 Domain of unknown function (DUF1898)
Sequence:
(in bold interface residues)
1 MPQLGGGRGGAGGGGGGSGAGATSGGDDLGANDELIPFQDEGGEEQEPSSDTASAQRDLD 60
61 EVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAEVRRPQDGAFFKGGAYPGYP 120
121 FLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQ 180
181 HPHHMHPLTPLITYSNDHFSPASPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQ 240
241 IPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFPHMVAPAHPGLPTSG 300
301 IPHPAIVSPIVKQEPAAPSLSPAVSAKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKV 360
361 VAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHAQLYPTWSARDNYGKKKK 420
421 RKREKQLSQTQSQQQIQEAEGALASKSKKPCIQYLPPEKPCDSPASSHGSALDSPATPSA 480
481 ALASPAAPAATHSEQAQPLSLTTKPEARAQLALHSAAFLSAKAAASNSSQMGSQPPLLSR 540
541 PLPLGSMPAALLTSPPTFPATLHAHQALPVLQAQPLSLVTKSAH
Interface Residues: 344, 347, 349, 350, 353, 357, 368, 369, 370, 373, 411, 413, 414, 415, 418
3D-footprint Homologues: 7m5w_A, 2gzk_A, 4s2q_D, 2lef_A, 4y60_C, 1j5n_A, 3f27_D, 6jrp_D, 1o4x_B, 3u2b_C, 1hry_A, 8a5p_G
Binding Motifs: PB0082.1 twwasATCAAAGgrwww
PB0186.1 rgssgaawawaaaww
MA0522.1 smCAGCTGCwg
Binding Sites: MA0522.1.13
MA0522.1.9
MA0522.1.11
MA0522.1.12
MA0522.1.1
MA0522.1.10
MA0522.1.14
MA0522.1.15
MA0522.1.16
MA0522.1.17
MA0522.1.18
MA0522.1.19
MA0522.1.2
MA0522.1.20
MA0522.1.3
MA0522.1.4
MA0522.1.5
MA0522.1.6
MA0522.1.7
MA0522.1.8
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

Kophengnavong T, Michnowicz J.E, Blackwell T.K. Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations. Molecular and cellular biology 20:261-72 (2000). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.