Transcription Factor

Accessions: UP00101A (UniPROBE 20160601)
Names: Sox-12, SOX-12 protein, Sox12, SRY-box containing gene 12
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q04890
Description: SRY-box containing gene 12
Length: 101
Pfam Domains: 17-85 HMG (high mobility group) box
18-75 Domain of unknown function (DUF1898)
Sequence:
(in bold interface residues)
1 AEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQD 60
61 SEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARP
Interface Residues: 19, 22, 24, 25, 28, 32, 43, 44, 45, 48, 86, 90, 100
3D-footprint Homologues: 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1hry_A, 3tq6_B, 1ckt_A
Binding Motifs: UP00101A_1 twATTGTTcthawh
UP00101A_2 mmwyasACAAAGrawt
Binding Sites: AAAACAAT
AAACAATT
AACAAAGA
AACAAAGG
AACAATAA
AACAATAG
AACAATTG
AAGACAAT
AATTGTTA
AATTGTTC
ACAAAGAA
ACAACAAT
AGAACAAT
AGACAATA
ATTGTTAA
ATTGTTCA
ATTGTTCG
CTTTGTTC
GAACAATA
TAACAATA
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.