Transcription Factor
| Accessions: | DMBX1_DBD (HumanTF 1.0), DMBX1 (HT-SELEX2 May2017) |
| Names: | Diencephalon/mesencephalon homeobox protein 1, DMBX1, DMBX1_HUMAN, Orthodenticle homolog 3, Paired-like homeobox protein DMBX1, ENSG00000197587 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q8NFW5 |
| Notes: | Ensembl ID: ENSG00000197587; DNA-binding domain sequence; TF family: homeodomain; Clone source: Megaman, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 117 |
| Pfam Domains: | 29-85 Homeobox domain |
| Sequence: (in bold interface residues) | 1 TLAERLAGSTGQAYIILEARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRER 60 61 LAMCTNLPEARVQVWFKNRRAKFRKKQRSLQKEQLQKQKEAEGSHGEGKAEAPTPDT |
| Interface Residues: | 28, 29, 30, 31, 32, 70, 71, 73, 74, 77, 78, 81, 82, 85 |
| 3D-footprint Homologues: | 4j19_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 1b72_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | DMBX1_DBD rsGGATTArs DMBX1_2 sTAATCcs DMBX1_methyl_1 cTAATCCc |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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