Transcription Factor

Accessions: ZNF787 (HT-SELEX2 May2017)
Names: ENSG00000142409, ZNF787
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4
Length: 383
Pfam Domains: 66-88 C2H2-type zinc finger
66-88 Zinc finger, C2H2 type
66-88 C2H2-type zinc finger
81-104 Zinc-finger double domain
96-114 C2H2-type zinc finger
96-116 Zinc finger, C2H2 type
96-116 C2H2-type zinc finger
108-132 Zinc-finger double domain
122-142 C2H2-type zinc finger
122-144 Zinc finger, C2H2 type
122-144 C2H2-type zinc finger
136-161 Zinc-finger double domain
149-173 C2H2-type zinc finger
150-172 Zinc finger, C2H2 type
150-172 C2H2-type zinc finger
164-188 Zinc-finger double domain
178-200 C2H2-type zinc finger
178-188 C2H2-type zinc finger
178-200 Zinc finger, C2H2 type
280-303 C2H2-type zinc finger
280-303 Zinc finger, C2H2 type
317-337 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MELREEAWSPGPLDSEDQQMASHENPVDILIMDDDDVPSWPPTKLSPPQSAPPAGPPPRP 60
61 RPPAPYICNECGKSFSHWSKLTRHQRTHTGERPNACADCGKTFSQSSHLVQHRRIHTGEK 120
121 PYACLECGKRFSWSSNLMQHQRIHTGEKPYTCPDCGRSFTQSKSLAKHRRSHSGLKPFVC 180
181 PRCGRGFSQPKSLARHLRLHPELSGPGVAAKVLAASVRRAKGPEEAVAADGEIAIPVGDG 240
241 EGIIVVGAPGEGAAAAAAMAGAGAKAAGPRSRRAPAPKPYVCLECGKGFGHGAGLLAHQR 300
301 AQHGDGLGAAGGEEPAHICVECGEGFVQGAALRRHKKIHAVGAPSVCSSCGQSYYRAGGE 360
361 EEDDDDDEAAGGRCPECRGGEGR
Interface Residues: 76, 77, 78, 79, 80, 82, 83, 84, 87, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 117, 132, 133, 134, 135, 136, 139, 142, 146, 147, 160, 161, 162, 163, 164, 165, 166, 167, 188, 189, 190, 191, 192, 194, 195, 199, 228, 229, 230, 231, 232, 235, 238, 255, 258, 270, 275, 289, 291, 292, 293, 294, 297, 301, 327, 328, 329, 330, 331, 355, 356, 358
3D-footprint Homologues: 1tf3_A, 7w1m_H, 7n5w_A, 5k5l_F, 1tf6_A, 5yel_A, 5kkq_D, 8gn3_A, 5ei9_F, 4m9v_C, 7ysf_A, 2lt7_A, 6e94_A, 1ubd_C, 6jnm_A, 7txc_E, 2kmk_A, 6ml4_A, 8ssq_A, 6blw_A, 6u9q_A, 2gli_A, 8ssu_A, 5yj3_D, 8h9h_G, 2jpa_A, 3uk3_C, 8cuc_F, 7y3l_A, 5k5i_A, 5v3j_F, 1f2i_J, 4x9j_A, 1g2f_F, 2wbs_A, 1llm_D, 5kl3_A, 6a57_A, 1yuj_A, 2drp_D, 7y3m_I
Binding Motifs: ZNF787_3 rATGCAccwwcssTGCCTCr
ZNF787_4 tgCCTCAGTTTmCCy
ZNF787_methyl_1 tgCCTCAGTTTmCCy
ZNF787_methyl_2 rATGCAckkwsygTGCCTCr
Related annotations: PaperBLAST

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