Transcription Factor
| Accessions: | Q9UQR1 (JASPAR 2024) |
| Names: | Transcription factor ZBP-89, Zinc finger DNA-binding protein 89, Zinc finger protein 148, ZN148_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 794 |
| Pfam Domains: | 171-193 Zinc finger, C2H2 type 171-190 C2H2-type zinc finger 185-208 Zinc-finger double domain 199-221 Zinc finger, C2H2 type 199-221 C2H2-type zinc finger 214-236 Zinc-finger double domain 227-249 C2H2-type zinc finger 227-249 Zinc finger, C2H2 type 242-265 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAA 60 61 DEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITF 120 121 TDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAF 180 181 RTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKY 240 241 HMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEED 300 301 SGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYM 360 361 VAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEES 420 421 KVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAA 480 481 SNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEV 540 541 LQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKAN 600 601 MLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFR 660 661 SGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPV 720 721 HQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAG 780 781 MTSSPDATTGQTFG |
| Interface Residues: | 181, 182, 183, 184, 185, 187, 188, 190, 191, 194, 209, 210, 211, 212, 213, 216, 220, 237, 238, 239, 240, 241, 244, 266, 267, 268, 269, 271, 272 |
| 3D-footprint Homologues: | 1tf3_A, 7n5w_A, 8ssu_A, 2gli_A, 5v3j_F, 1tf6_A, 1ubd_C, 8ssq_A, 7w1m_H, 2kmk_A, 6u9q_A, 8h9h_G, 2lt7_A, 7y3m_I, 7ysf_A, 6e94_A, 2jpa_A, 7y3l_A, 8cuc_F, 7txc_E, 8gn3_A, 2drp_D |
| Binding Motifs: | MA1653.1 ysCCCCTCCCcc MA1653.2 CCCCTCCCcc |
| Binding Sites: | MA1653.1.1 / MA1653.1.2 MA1653.1.10 MA1653.1.11 / MA1653.1.2 / MA1653.1.3 / MA1653.1.5 MA1653.1.12 / MA1653.1.6 MA1653.1.13 / MA1653.1.7 MA1653.1.14 / MA1653.1.8 MA1653.1.15 / MA1653.1.9 MA1653.1.16 MA1653.1.11 / MA1653.1.17 MA1653.1.12 / MA1653.1.18 MA1653.1.19 MA1653.1.13 / MA1653.1.20 MA1653.1.3 MA1653.1.4 MA1653.1.5 MA1653.1.6 MA1653.1.7 MA1653.1.8 MA1653.1.4 / MA1653.1.9 MA1653.1.1 MA1653.1.10 MA1653.1.14 MA1653.1.15 MA1653.1.16 MA1653.1.17 MA1653.1.18 MA1653.1.19 MA1653.1.20 MA1653.2.9 MA1653.2.1 MA1653.2.10 MA1653.2.11 MA1653.2.12 / MA1653.2.19 / MA1653.2.3 / MA1653.2.5 MA1653.2.13 MA1653.2.14 MA1653.2.15 / MA1653.2.7 MA1653.2.16 / MA1653.2.4 MA1653.2.17 MA1653.2.18 MA1653.2.2 MA1653.2.20 MA1653.2.6 MA1653.2.8 |
| Publications: | De Bustos C, Smits A, Strömberg B, Collins VP, Nistér M, Afink G. A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas. J Med Genet 42:31-7 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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